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4yxj

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==Structure of Thermotoga maritima DisA in complex with ApCpp==
==Structure of Thermotoga maritima DisA in complex with ApCpp==
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<StructureSection load='4yxj' size='340' side='right' caption='[[4yxj]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='4yxj' size='340' side='right'caption='[[4yxj]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c1y|3c1y]], [[3c1z|3c1z]], [[3c21|3c21]], [[3c23|3c23]], [[4yvz|4yvz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [https://pdbe.org/4yxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [https://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [http://pdbe.org/4yxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [http://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
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[https://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Diadenylate cyclase]]
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[[Category: Large Structures]]
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[[Category: Deimling, T]]
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[[Category: Thermotoga maritima]]
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[[Category: Hopfner, K P]]
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[[Category: Deimling T]]
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[[Category: Mueller, M]]
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[[Category: Hopfner K-P]]
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[[Category: Witte, G]]
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[[Category: Mueller M]]
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[[Category: C-di-amp synthesis]]
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[[Category: Witte G]]
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[[Category: Dac domain]]
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[[Category: Dna binding protein]]
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[[Category: Inhibitor]]
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[[Category: Pre-reaction state]]
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[[Category: Transferase]]
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Current revision

Structure of Thermotoga maritima DisA in complex with ApCpp

PDB ID 4yxj

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