4yz7

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==Crystal structure of Piratoxin I (PrTX-I) complexed to aristolochic acid==
==Crystal structure of Piratoxin I (PrTX-I) complexed to aristolochic acid==
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<StructureSection load='4yz7' size='340' side='right' caption='[[4yz7]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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<StructureSection load='4yz7' size='340' side='right'caption='[[4yz7]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yz7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_pirajai Bothrops pirajai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZ7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yz7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pirajai Bothrops pirajai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZ7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9AR:9-HYDROXY+ARISTOLOCHIC+ACID'>9AR</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9589&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yz7 OCA], [http://pdbe.org/4yz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yz7 RCSB], [http://www.ebi.ac.uk/pdbsum/4yz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yz7 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9AR:9-HYDROXY+ARISTOLOCHIC+ACID'>9AR</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yz7 OCA], [https://pdbe.org/4yz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yz7 RCSB], [https://www.ebi.ac.uk/pdbsum/4yz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yz7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI]] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).<ref>PMID:7660366</ref> <ref>PMID:22205953</ref>
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[https://www.uniprot.org/uniprot/PA2H1_BOTPI PA2H1_BOTPI] Snake venom phospholipase A2 (PLA2) homolog that lacks enzymatic activity, but displays myotoxin and edema-inducing activities in vivo. In vitro neuromuscular activities have also been observed, but they are not found in vivo and can be explained by the destabilization of the muscle membrane by the toxin. The myotoxic activity is inhibited by rosmarinic acid (RA).<ref>PMID:7660366</ref> <ref>PMID:22205953</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yz7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yz7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 homolog|Phospholipase A2 homolog]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bothrops pirajai]]
[[Category: Bothrops pirajai]]
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[[Category: Fernandes, C A.H]]
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[[Category: Large Structures]]
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[[Category: Fontes, M R.M]]
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[[Category: Fernandes CAH]]
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[[Category: Inhibitor]]
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[[Category: Fontes MRM]]
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[[Category: Phospholipase a2]]
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[[Category: Phospholipase a2-like]]
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[[Category: Toxin]]
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Current revision

Crystal structure of Piratoxin I (PrTX-I) complexed to aristolochic acid

PDB ID 4yz7

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