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Exotoxin

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== Structural highlights ==
== Structural highlights ==
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<scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.
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<scene name='59/593276/Cv/4'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.
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</StructureSection>
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==3D structures of exotoxin==
==3D structures of exotoxin==
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[[Exotoxin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*''Pseudomonas aeruginosa'' exotoxin
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**[[1ikq]] – PaET A <br />
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**[[1ikp]] – PaET A (mutant) <br />
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**[[1dma]] – PaET A catalytic domain + nicotinamide + AMP <br />
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**[[1aer]] – PaET A catalytic domain + NAD analog + AMP <br />
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**[[1xk9]] – PaET A catalytic domain + inhibitor <br />
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**[[1zm2]] – PaET A catalytic domain + diphthamide + adenosine diphosphoribose + EF-2 <br />
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**[[1zm3]] – PaET A catalytic domain + diphthamide + EF-2 <br />
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**[[3b78]], [[2zit]] – PaET A catalytic domain + diphthamide + NAD + EF-2 <br />
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**[[3b82]], [[3b8h]] – PaET A catalytic domain (mutant) + diphthamide + NAD + EF-2 <br />
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**[[1zm4]] – PaET A catalytic domain + diphthamide + NAD analog + EF-2 <br />
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**[[1zm9]] – PaET A catalytic domain + diphthamide + inhibitor + EF-2 <br />
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*''Vibrio cholerae'' exotoxin
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**[[2q5t]] – VcET <br />
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**[[2q6m]], [[3ess]], [[3ki0]], [[3ki1]], [[3ki2]], [[3ki3]], [[3ki4]], [[3ki5]], [[3ki6]], [[3ki7]], [[3ny6]] – VcET catalytic domain + inhibitor <br />
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**[[3q9o]] – VcET + NAD <br />
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*''Streptococcus pyogenes'' exotoxin
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**[[1b1z]], [[1fnu]], [[1fnv]], [[1fnw]] – SpET A1 <br />
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**[[1dki]] – SpET B<br />
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**[[2jtc]] – SpET B (mutant) - NMR<br />
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**[[1an8]] – SpET C<br />
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**[[1et9]] – SpET H<br />
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**[[2ici]] – SpET I<br />
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**[[1ty0]] – SpET J<br />
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**[[1ha5]], [[1uup]] – SpET A1 + Zn<br />
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**[[1l0x]] – SpET A1 (mutant) + T cell receptor β chain<br />
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**[[1pvj]] – SpET B + inhibitor <br />
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**[[2uzj]] – SpET B + guanidine derivative <br />
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**[[1eu4]] – SpET H + Zn<br />
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**[[1ty2]] – SpET J + Zn<br />
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**[[1ktk]] – SpET C (mutant) + T cell receptor β chain<br />
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**[[1l0y]] – SpET A1 (mutant) + T cell receptor β chain + Zn<br />
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**[[1hqr]] – SpRT C + antibody + myelin basic protein<br />
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*''Staphylococcus aureus'' exotoxin
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**[[3ury]] – SaET <br />
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**[[1v1o]], [[1v1p]] – SaET 1 <br />
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**[[2r61]], [[2z8l]] – SaET 3<br />
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**[[3r2i]] – SaET 5<br />
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**[[4zys]] – SaET 6<br />
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**[[3o13]] – SaET 15<br />
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**[[3kls]] – SaET 1 (mutant) + complement C5<br />
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*''Corynebacterium diphtheriae'' exotoxin See [[Diphtheria toxin]]
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}}
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== References ==
== References ==

Current revision

Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code 3q9o).

Drag the structure with the mouse to rotate

References

  1. ↑ Hamon MA, Batsche E, Regnault B, Tham TN, Seveau S, Muchardt C, Cossart P. Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13467-72. Epub 2007 Aug 3. PMID:17675409 doi:http://dx.doi.org/10.1073/pnas.0702729104
  2. ↑ Fieldhouse RJ, Jorgensen R, Lugo MR, Merrill AR. The 1.8 angstrom cholix toxin crystal structure in complex with NAD and evidence for a new kinetic model. J Biol Chem. 2012 Apr 25. PMID:22535961 doi:10.1074/jbc.M111.337311

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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