This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Fibronectin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:14, 1 July 2019) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 16: Line 16:
<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).
<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).
-
</StructureSection>
 
== 3D Structures of Fibronectin ==
== 3D Structures of Fibronectin ==
 +
[[Fibronectin 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
* Fn module FnI
+
-
 
+
-
**[[3m7p]] – hFn GBD – human<br />
+
-
**[[1e8b]], [[1e88]], [[1qo6]] - hFn GBD – NMR<br />
+
-
**[[3gxe]], [[3ejh]] – hFnI<sub>8-9</sub> +collagen alpha-1<br />
+
-
**[[1fbr]] - hFnI<sub>4-5</sub> - NMR<br />
+
-
**[[2rky]], [[2rl0]] – hFnI<sub>4-5</sub>+Fn binding peptide<br />
+
-
**[[2rkz]], [[3cal]], [[3zrz]] - hFn<sub>2-3</sub> +Fn binding peptide<br />
+
-
**[[2cg6]], [[2cg7]] - hFnI<sub>2-3</sub><br />
+
-
**[[2cku]] - hFnI<sub>2-3</sub> – NMR<br />
+
-
**[[1o9a]] - hFnI<sub>1-2</sub>+B3 from FNBB – NMR<br />
+
-
**[[2ec3]] – hFnI<sub>11</sub> – NMR<br />
+
-
**[[3r8q]] – hFnI<sub>12-14</sub><br />
+
-
**[[1qgb]] – hFn FnI N-terminal - NMR<br />
+
-
**[[2ck2]] – hFn (mutant) core swapped<br />
+
-
**[[1j8k]] – hFn extra domain 2 – NMR<br />
+
-
**[[1fnh]] – hFn heparin and integrin binding domains<br />
+
-
**[[2qbw]], [[3ch8]] – hFn-PDZ fusion<br />
+
-
**[[4gh7]] – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
+
-
 
+
-
* Fn module FnII
+
-
 
+
-
**[[2fn2]] – hFnII<sub>2</sub> – NMR
+
-
 
+
-
* Fn module FnIII
+
-
 
+
-
**[[1q38]], [[1x3d]], [[1x4x]], [[1x5x]] - hFn FnIII – NMR<br />
+
-
**[[2h41]], [[2h45]] – hFnIII<sub>2</sub> – NMR<br />
+
-
**[[1oww]] - hFnIII<sub>1</sub> – NMR<br />
+
-
**[[2ha1]] - hFnIII<sub>1-2</sub> – NMR<br />
+
-
**[[2crm]] - hFnIII<sub>4</sub> – NMR<br />
+
-
**[[2crz]] - hFnIII<sub>5</sub> – NMR<br />
+
-
**[[1fna]], [[1ttf]], [[1ttg]] – hFnIII<sub>10</sub><br />
+
-
**[[4mmx]] - hFnIII<sub>10</sub> + integrin α V + integrin β 3<br />
+
-
**[[4mmy]], [[4mmz]] - hFnIII<sub>10</sub> (mutant) + integrin α V + integrin β 3<br />
+
-
**[[2ocf]] - hFnIII<sub>10</sub>+estrogen receptor ligand-binding domain<br />
+
-
**[[1fnf]] – hFnIII<sub>7-10</sub><br />
+
-
**[[2fnb]] – hFn FnIII ed-b domain – NMR<br />
+
-
**[[1mfn]], [[2mfn]] – FnIII<sub>9-10</sub> – mouse - NMR<br />
+
-
**[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens''
+
-
 
+
-
* Fn module FnI+FnII
+
-
**[[3mql]] – hFnI<sub>6</sub>+FnII<sub>2</sub>+FnI<sub>7</sub>
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code 3m7p)

Drag the structure with the mouse to rotate

References

  1. ↑ Pankov R, Yamada KM. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. PMID:12244123
  2. ↑ Han S, Khuri FR, Roman J. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res. 2006 Jan 1;66(1):315-23. PMID:16397245 doi:http://dx.doi.org/10.1158/0008-5472.CAN-05-2367

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Fibronectin"
Personal tools