5xkm

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'''Unreleased structure'''
 
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The entry 5xkm is ON HOLD
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==Crystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide==
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<StructureSection load='5xkm' size='340' side='right'caption='[[5xkm]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xkm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XKM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=87R:6-methyl-N-[(1R)-1-[4-(trifluoromethyloxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide'>87R</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xkm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xkm OCA], [https://pdbe.org/5xkm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xkm RCSB], [https://www.ebi.ac.uk/pdbsum/5xkm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xkm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
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Authors: Oki, H., Kondo, M., Snell, G., Lane, W.
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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Description: Crystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Snell, G]]
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__TOC__
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[[Category: Lane, W]]
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</StructureSection>
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[[Category: Oki, H]]
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[[Category: Homo sapiens]]
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[[Category: Kondo, M]]
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[[Category: Large Structures]]
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[[Category: Kondo M]]
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[[Category: Lane W]]
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[[Category: Oki H]]
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[[Category: Snell G]]

Current revision

Crystal structure of human phosphodiesterase 2A in complex with 6-methyl-N-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

PDB ID 5xkm

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