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5n1x

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==Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand==
==Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand==
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<StructureSection load='5n1x' size='340' side='right' caption='[[5n1x]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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<StructureSection load='5n1x' size='340' side='right'caption='[[5n1x]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n1x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N1X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n1x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N1X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8HH:~{N}-ETHYL-5-PYRIDIN-3-YL-PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>8HH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1x OCA], [http://pdbe.org/5n1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n1x RCSB], [http://www.ebi.ac.uk/pdbsum/5n1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1x ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HH:~{N}-ETHYL-5-PYRIDIN-3-YL-PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>8HH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n1x OCA], [https://pdbe.org/5n1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n1x RCSB], [https://www.ebi.ac.uk/pdbsum/5n1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n1x ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
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[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5n1x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5n1x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ferguson, A]]
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[[Category: Homo sapiens]]
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[[Category: Hargreaves, D]]
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[[Category: Large Structures]]
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[[Category: Robb, G]]
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[[Category: Ferguson A]]
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[[Category: Kinase]]
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[[Category: Hargreaves D]]
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[[Category: Transferase]]
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[[Category: Robb G]]

Current revision

Crystal structure of the BCL6 BTB domain in complex with pyrazolo-pyrimidine ligand

PDB ID 5n1x

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