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5t4i

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==A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme==
==A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme==
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<StructureSection load='5t4i' size='340' side='right' caption='[[5t4i]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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<StructureSection load='5t4i' size='340' side='right'caption='[[5t4i]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t4i]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T4I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t4i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_launch_vector_pDE-GFP2 DNA launch vector pDE-GFP2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T4I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.389&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5t3v|5t3v]], [[5t40|5t40]], [[5t5c|5t5c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4i OCA], [http://pdbe.org/5t4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t4i RCSB], [http://www.ebi.ac.uk/pdbsum/5t4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4i OCA], [https://pdbe.org/5t4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t4i RCSB], [https://www.ebi.ac.uk/pdbsum/5t4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/EXOG_HUMAN EXOG_HUMAN]] Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.<ref>PMID:18187503</ref>
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[https://www.uniprot.org/uniprot/EXOG_HUMAN EXOG_HUMAN] Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.<ref>PMID:18187503</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Szymanski, M R]]
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[[Category: DNA launch vector pDE-GFP2]]
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[[Category: Yin, W Y]]
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[[Category: Homo sapiens]]
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[[Category: Complex]]
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[[Category: Large Structures]]
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[[Category: Dna-repair]]
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[[Category: Szymanski MR]]
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[[Category: Exonuclease]]
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[[Category: Yin WY]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Mitochondria]]
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Current revision

A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme

PDB ID 5t4i

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