5gt9

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==The X-ray structure of 7beta-hydroxysteroid dehydrogenase==
==The X-ray structure of 7beta-hydroxysteroid dehydrogenase==
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<StructureSection load='5gt9' size='340' side='right' caption='[[5gt9]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='5gt9' size='340' side='right'caption='[[5gt9]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gt9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GT9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gt9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Collinsella_aerofaciens_ATCC_25986 Collinsella aerofaciens ATCC 25986]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GT9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gt9 OCA], [http://pdbe.org/5gt9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gt9 RCSB], [http://www.ebi.ac.uk/pdbsum/5gt9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gt9 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gt9 OCA], [https://pdbe.org/5gt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gt9 RCSB], [https://www.ebi.ac.uk/pdbsum/5gt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gt9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HSDHB_COLAA HSDHB_COLAA] 7beta-hydroxysteroid dehydrogenase that catalyzes the reduction of the 7-oxo group of 7-oxo-lithocholate (7-oxo-LCA), to yield ursodeoxycholate (UDCA) (PubMed:21181147, PubMed:6954878, PubMed:27006087). As C.aerofaciens is an intestinal bacterium, this enzyme probably contributes to the formation of UDCA in the human colon. UDCA is regarded as a chemopreventive beneficial secondary bile acid due to its low hydrophobicity; it protects hepatocytes and bile duct epithelial cells against necrosis and apoptosis induced by more hydrophobic secondary bile acids like deoxycholate (DCA) (Probable). This enzyme is also able to catalyze the reverse reaction, i.e. the oxidation of the 7beta-hydroxy group of UDCA to 7-oxo-LCA (PubMed:21181147, PubMed:6954878). To a lesser extent, is also active on the taurine- and glycine-conjugates of ursodeoxycholate. It is specific for NADPH/NADP(+) as the electron acceptor/donor since it is not active with NADH/NAD(+) (PubMed:6954878). In the presence of NADPH, 7beta-HSDH can also reduce dehydrocholate (PubMed:21181147). And is also able to oxidize ursocholate (PubMed:27006087).<ref>PMID:21181147</ref> <ref>PMID:27006087</ref> <ref>PMID:6954878</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5gt9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5gt9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, Q]]
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[[Category: Collinsella aerofaciens ATCC 25986]]
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[[Category: Huo, X]]
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[[Category: Large Structures]]
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[[Category: Lv, Z]]
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[[Category: Chen Q]]
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[[Category: Wang, F]]
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[[Category: Huo X]]
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[[Category: Wang, R]]
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[[Category: Lv Z]]
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[[Category: Oxidoreductase]]
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[[Category: Wang F]]
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[[Category: Short chain dehydrogenase]]
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[[Category: Wang R]]
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[[Category: Steroid substrate]]
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Current revision

The X-ray structure of 7beta-hydroxysteroid dehydrogenase

PDB ID 5gt9

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