Flavin reductase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' scene='49/490853/Cv/1' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '> |
== Function == | == Function == | ||
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== Structural insights == | == Structural insights == | ||
| - | The <scene name='49/490853/Cv/ | + | The <scene name='49/490853/Cv/4'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref> |
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *NADPH-dependent Flavin reductase or biliverdin IX beta reductase | |
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| + | **[[8ell]], [[8elm]] – hFR – human | ||
| + | **[[1hdo]], [[7er6]], [[9c18]] - hFR + NADP <br /> | ||
| + | **[[6opl]] – hFR (mutant) + NADP <br /> | ||
| + | **[[1he2]] - hFR + biliverdin IX α + NADP<BR /> | ||
| + | **[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR /> | ||
| + | **[[1he4]] - hFR + FMN + NADP<BR /> | ||
| + | **[[1he5]] - hFR + lumichrome + NADP<BR /> | ||
| + | **[[5ooh]] – hFR + NADP + erythrosine<br /> | ||
| + | **[[5oog]] – hFR + NADP + phloxine + cyanosine<br /> | ||
| + | **[[7er7]], [[7er8]], [[7er9]], [[7era]], [[7erb]], [[7erc]], [[7erd]], [[7ere]] – hFR + NADP + drug<br /> | ||
| + | **[[8k4k]], [[9c16]], [[9c17]] – hFR + NADP + inhibitor<br /> | ||
| + | **[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br /> | ||
| + | **[[5cho]] - FR + FAD – uncultured bacteria<br /> | ||
| + | **[[1qfj]] – FR – ''Escherichia coli''<br /> | ||
| + | **[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br /> | ||
| + | **[[2bkj]] - VhFR + NAD + FMN<br /> | ||
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| + | *NADH-dependent Flavin reductase | ||
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| + | **[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br /> | ||
| + | **[[1rz1]] - GtFR + FAD + NAD<br /> | ||
| + | **[[5n6q]] - PpFR + FMN – ''Pseudomonas putida''<br /> | ||
| + | **[[4uth]] - PpFR (mutant) + FMN <br /> | ||
| + | **[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br /> | ||
| + | **[[2d36]] - StFR + FMN – ''Sulfurisphaera tokodaii''<br /> | ||
| + | **[[2d37]] - StFR + FMN + NAD<br /> | ||
| + | **[[2d38]] - StFR + FMN + NADP<br /> | ||
| + | **[[9fd4]], [[9fd5]] - FR + FAD – ''Streptomyces albogriseolus''<br /> | ||
| + | **[[8ct0]] - FR + FAD + NAD – ''Kitasatospora aureofaciens''<br /> | ||
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| + | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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3D structures of flavin reductase
Updated on 06-July-2025
References
- ↑ Yubisui T, Takeshita M, Yoneyama Y. Reduction of methemoglobin through flavin at the physiological concentration by NADPH-flavin reductase of human erythrocytes. J Biochem. 1980 Jun;87(6):1715-20. PMID:7400118
- ↑ Pereira PJ, Macedo-Ribeiro S, Parraga A, Perez-Luque R, Cunningham O, Darcy K, Mantle TJ, Coll M. Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. Nat Struct Biol. 2001 Mar;8(3):215-20. PMID:11224564 doi:10.1038/84948
