Gcn4

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<StructureSection load='2dgc' size='350' side='right' caption='Structure of Gcn4 leucine zipper domain complex with DNA (PDB entry [[2dgc]])' scene='54/540145/Cv/1'>
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<StructureSection load='2dgc' size='350' side='right' caption='Structure of Gcn4 leucine zipper domain complex with DNA (PDB entry [[2dgc]])' scene=''54/540145/Biological_assembly/1''>
== Function ==
== Function ==
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'''Gcn4''' is a yeast transcriptional activator. It belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. <ref>PMID:7934812</ref> Gcn4-pLI is a 33-residue peptide of the dimerization domain of Gcn4. See also [[Intrinsically Disordered Protein]].
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'''Gcn4''' or '''General control protein Gcn4''' is a yeast transcriptional activator. It belongs to a large family of eukaryotic transcription factors including Fos, Jun and CREB. <ref>PMID:7934812</ref> Gcn4-pLI is a 33-residue peptide of the dimerization domain of Gcn4. See also [[Intrinsically Disordered Protein]].
== Structural highlights ==
== Structural highlights ==
Gcn4 and other family members have a DNA recognition motif consisting of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a Gcn4 binding site induces the transition of this region from unstructured to α-helical.
Gcn4 and other family members have a DNA recognition motif consisting of a coiled-coil dimerization element, the leucine-zipper, and an adjoining basic region, which mediates DNA binding. This basic region is largely unstructured in the absence of DNA, addition of DNA containing a Gcn4 binding site induces the transition of this region from unstructured to α-helical.
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</StructureSection>
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See [[Coiled coil]].
== 3D Structures of Gcn4 ==
== 3D Structures of Gcn4 ==
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[[Gcn4 3D Structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Gcn4 coiled-coil domain
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**[[2zta]], [[1w5i]], [[2b1f]], [[2b22]], [[2ag3]], [[2r2v]], [[4c46]], [[4hu5]], [[4hu6]] – yGcn4 - yeast <br />
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**[[2ovn]], [[2l56]], [[5iir]], [[5iiv]], [[5iew]] – yGcn4 - NMR<br />
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**[[3ck4]], [[3crp]], [[2ipz]] – yGcn4 tetramer <br />
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**[[1gcl]], [[1swi]], [[1ce9]], [[1w5g]], [[1w5h]], [[1w5j]], [[1w5k]], [[1w5l]], [[1unt]], [[1unu]], [[1unv]], [[1unw]], [[1unx]], [[1uny]], [[1unz]], [[1uo0]], [[1uo1]], [[1uo2]], [[1uo3]], [[1uo4]], [[1uo5]], [[1u9f]], [[1u9g]], [[1u9h]], [[2bni]], [[2cce]], [[2ccf]], [[2ccn]], [[2ahp]], [[2hy6]], [[3i1g]], [[2wpy]], [[2wpz]], [[2wq0]], [[2wq1]], [[2wq2]], [[2wq3]], [[3k7z]], [[3gjp]], [[3m48]], [[4niz]], [[4nj0]], [[4nj1]], [[4nj2]], [[4tl1]], [[5apq]], [[5aps]], [[5apt]], [[5apu]], [[5apv]], [[5apw]], [[5apx]], [[5apy]] – yGcn4 (mutant)<br />
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**[[1zii]], [[1zik]], [[1zil]] – yGcn4 dimer (mutant)<br />
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**[[2o7h]], [[1gcm]], [[1zij]], [[1zim]], [[1piq]], [[1ij0]], [[1ij1]], [[1ij2]], [[1ij3]], [[1rb4]], [[1rb5]], [[1rb6]] – yGcn4 trimer (mutant)<br />
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**[[2nrn]] – yGcn4 tetramer (mutant)<br />
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**[[1fmh]] – yGcn4 dimer (mutant) - NMR<br />
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**[[1ysa]], [[1dgc]], [[2dgc]] – yGcn4 dimer + DNA <br />
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*Gcn4-pLI
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**[[2ag3]], [[2oxj]], [[2oxk]] – yGcn4-pLI (br />
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**[[1u2u]] – yGcn4-pLI dimer - NMR<br />
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**[[4dmd]], [[1kd8]], [[1kd9]], [[1kdd]] – yGcn4-pLI dimer <br />
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**[[4dme]] – yGcn4-pLI trimer <br />
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**[[1c94]] – yGcn4-pLI retro<br />
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*Gcn4 transcription activation domain
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**[[2lpb]] – yGcn4 + mediator of RNA polymerase II<br />
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*Gcn4 fusion proteins
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**[[1gk6]] – yGcn4/vimentin<br />
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**[[2wg5]] – yGcn4/proteasome-activating nucleotidase<br />
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**[[2wg6]] – yGcn4 (mutant)/proteasome-activating nucleotidase<br />
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**[[2yny]], [[2ynz]], [[2yo0]], [[2yo1]], [[2yo2]], [[2yo3]], [[3zmf]] – yGcn4/inner membrane protein<br />
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**[[5app]] – yGcn4/outer membrane protein 100<br />
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**[[5apz]] – yGcn4/NOR1<br />
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**[[3i5c]] – yGcn4/WSPR response regulator<br />
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**[[3p8m]] – yGcn4/dynein<br />
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**[[4g2k]], [[1env]], [[1fav]], [[1gcl]], [[2q5u]], [[2q7c]], [[3g9r]] – yGcn4/virus envelope glycoprotein<br />
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**[[1kql]], [[2z5i]] – yGcn4/α-tropomyosin<br />
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**[[2z5h]] – yGcn4/α-tropomyosin + troponin T<br />
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**[[3bas]], [[3bat]] – yGcn4/myosin<br />
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**[[1wvl]], [[2d3e]], [[2efr]], [[2efs]], [[2g9j]] – yGcn4/SAC7D + DNA<br />
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**[[4m8m]] – yGcn4/plexin<br />
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*Gcn4 complex with protein
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**[[1ld4]] – yGcn4 + virus coat protein + virus spike glycoprotein<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of Gcn4 leucine zipper domain complex with DNA (PDB entry 2dgc)

Drag the structure with the mouse to rotate

References

  1. ↑ Hinnebusch AG. Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2. Mol Microbiol. 1993 Oct;10(2):215-23. PMID:7934812

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Karsten Theis, Alexander Berchansky

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