5o0z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of laspartomycin C in complex with geranyl-phosphate== | |
| + | <StructureSection load='5o0z' size='340' side='right'caption='[[5o0z]], [[Resolution|resolution]] 1.28Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5o0z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_viridochromogenes Streptomyces viridochromogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O0Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2TL:D-ALLOTHREONINE'>2TL</scene>, <scene name='pdbligand=9GB:[(~{E})-3-methylhex-2-enyl]+dihydrogen+phosphate'>9GB</scene>, <scene name='pdbligand=9GE:(~{E})-13-methyltetradec-2-enoic+acid'>9GE</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CPI:6-CARBOXYPIPERIDINE'>CPI</scene>, <scene name='pdbligand=DNP:3-AMINO-ALANINE'>DNP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o0z OCA], [https://pdbe.org/5o0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o0z RCSB], [https://www.ebi.ac.uk/pdbsum/5o0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o0z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The calcium-dependent antibiotics (CDAs) are an important emerging class of antibiotics. We here report the crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl-phosphate at a resolution of 1.28 A. This represents the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55-P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target. | ||
| - | + | High-resolution crystal structure reveals molecular details of target recognition by the calcium-dependent lipopeptide antibiotic laspartomycin C.,Kleijn LHJ, Vlieg HC, Wood TM, Sastre Torano J, Janssen BJC, Martin NI Angew Chem Int Ed Engl. 2017 Nov 6. doi: 10.1002/anie.201709240. PMID:29108098<ref>PMID:29108098</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5o0z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces viridochromogenes]] | ||
| + | [[Category: Janssen BJC]] | ||
| + | [[Category: Kleijn LHJ]] | ||
| + | [[Category: Martin NI]] | ||
| + | [[Category: Vlieg HC]] | ||
Current revision
Structure of laspartomycin C in complex with geranyl-phosphate
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