5xme

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(New page: '''Unreleased structure''' The entry 5xme is ON HOLD Authors: Lin, Z., Zhang, N. Description: Solution structure of C-terminal domain of TRADD Category: Unreleased Structures [[Cat...)
Current revision (07:28, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5xme is ON HOLD
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==Solution structure of C-terminal domain of TRADD==
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<StructureSection load='5xme' size='340' side='right'caption='[[5xme]]' scene=''>
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Authors: Lin, Z., Zhang, N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xme]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XME FirstGlance]. <br>
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Description: Solution structure of C-terminal domain of TRADD
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xme OCA], [https://pdbe.org/5xme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xme RCSB], [https://www.ebi.ac.uk/pdbsum/5xme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xme ProSAT]</span></td></tr>
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[[Category: Lin, Z]]
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</table>
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[[Category: Zhang, N]]
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== Function ==
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[https://www.uniprot.org/uniprot/TRADD_HUMAN TRADD_HUMAN] The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lin Z]]
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[[Category: Zhang N]]

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Solution structure of C-terminal domain of TRADD

PDB ID 5xme

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