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5x4q
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==Crystal structure of the BCL6 BTB domain in complex with Compound 7== | ==Crystal structure of the BCL6 BTB domain in complex with Compound 7== | ||
| - | <StructureSection load='5x4q' size='340' side='right' caption='[[5x4q]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='5x4q' size='340' side='right'caption='[[5x4q]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5x4q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X4Q OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5x4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X4Q FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7Z6:5-[[5-CHLORANYL-2-(PYRIDIN-3-YLMETHYLAMINO)PYRIMIDIN-4-YL]AMINO]-1,3-DIHYDROINDOL-2-ONE'>7Z6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7Z6:5-[[5-CHLORANYL-2-(PYRIDIN-3-YLMETHYLAMINO)PYRIMIDIN-4-YL]AMINO]-1,3-DIHYDROINDOL-2-ONE'>7Z6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x4q OCA], [https://pdbe.org/5x4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x4q RCSB], [https://www.ebi.ac.uk/pdbsum/5x4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x4q ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5x4q" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5x4q" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Ida K]] |
| - | [[Category: | + | [[Category: Lane W]] |
| - | [[Category: | + | [[Category: Snell G]] |
| - | [[Category: | + | [[Category: Sogabe S]] |
Current revision
Crystal structure of the BCL6 BTB domain in complex with Compound 7
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Categories: Homo sapiens | Large Structures | Ida K | Lane W | Snell G | Sogabe S
