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4zl4
From Proteopedia
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==Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)== | ==Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)== | ||
| - | <StructureSection load='4zl4' size='340' side='right' caption='[[4zl4]], [[Resolution|resolution]] 2.37Å' scene=''> | + | <StructureSection load='4zl4' size='340' side='right'caption='[[4zl4]], [[Resolution|resolution]] 2.37Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4zl4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZL4 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4zl4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZL4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PF:(2R)-1-[(2R)-2-(2-METHOXYETHOXY)PROPOXY]PROPAN-2-AMINE'>4PF</scene>, <scene name='pdbligand=4PK:N-[(BENZYLOXY)CARBONYL]-O-CARBAMIMIDAMIDO-L-HOMOSERYL-N-{(3S,4S)-3-HYDROXY-6-METHYL-1-OXO-1-[(2-PHENYLETHYL)AMINO]HEPTAN-4-YL}-L-VALINAMIDE'>4PK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4PF:(2R)-1-[(2R)-2-(2-METHOXYETHOXY)PROPOXY]PROPAN-2-AMINE'>4PF</scene>, <scene name='pdbligand=4PK:N-[(BENZYLOXY)CARBONYL]-O-CARBAMIMIDAMIDO-L-HOMOSERYL-N-{(3S,4S)-3-HYDROXY-6-METHYL-1-OXO-1-[(2-PHENYLETHYL)AMINO]HEPTAN-4-YL}-L-VALINAMIDE'>4PK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zl4 OCA], [https://pdbe.org/4zl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zl4 RCSB], [https://www.ebi.ac.uk/pdbsum/4zl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zl4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PLM5_PLAVS PLM5_PLAVS] During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence (PubMed:24983235). Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including EMP1 (By similarity). Also, by regulating protein export, plays an essential role in gametocyte development and thus parasite transmission to the mosquito vector (By similarity).[UniProtKB:Q8I6Z5][UniProtKB:W7JPD9]<ref>PMID:24983235</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4zl4" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4zl4" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Plasmepsin|Plasmepsin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Plasmodium vivax]] |
| - | [[Category: | + | [[Category: Boddey JA]] |
| - | [[Category: | + | [[Category: Cowman AF]] |
| - | [[Category: | + | [[Category: Czabotar PE]] |
| - | [[Category: | + | [[Category: Gazdic M]] |
| - | [[Category: | + | [[Category: Hodder AN]] |
| - | [[Category: | + | [[Category: Sleebs BE]] |
| - | [[Category: | + | [[Category: Smith BJ]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)
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