Sentrin-specific protease

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'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide<ref>PMID:24586832</ref>.
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'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide<ref>PMID:24586832</ref>.<br />
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*'''SENP2''' localised in cytoplasmic vesicles and nuclear body.
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*'''SENP7''' localised in breast epithelium.
<scene name='56/568937/Cv/1'>human Senp1 catalytic domain complex with SUMO1 and RanGAP C terminal</scene> (PDB entry [[2iy0]]).
<scene name='56/568937/Cv/1'>human Senp1 catalytic domain complex with SUMO1 and RanGAP C terminal</scene> (PDB entry [[2iy0]]).
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*Sentrin-specific protease 1
*Sentrin-specific protease 1
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**[[2ckg]], [[2iyc]] – hSenp1 C terminal – human<br />
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**[[2ckg]], [[2iyc]] – hSenp1 catalytic domain – human<br />
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**[[2xph]], [[2xre]] – hSenp1 C terminal + Co<br />
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**[[2xph]], [[2xre]] – hSenp1 catalytic domain + Co<br />
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**[[2ckh]], [[2iyd]] – hSenp1 C terminal + SUMO2<br />
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**[[2iy1]], [[2g4d]] – hSenp1 catalytic domain (mutant) + SUMO1<br />
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**[[2iy1]], [[2g4d]] – hSenp1 C terminal (mutant) + SUMO1<br />
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**[[2ckh]], [[2iyd]] – hSenp1 catalytic domain + SUMO2<br />
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**[[2iy0]] – hSenp1 C terminal + SUMO1 + RanGAP C terminal<br />
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**[[6nnq]] – hSenp1 catalytic domain + SUMO3<br />
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**[[2iy0]] – hSenp1 catalytic domain + SUMO1 + RanGAP C terminal<br />
*Sentrin-specific protease 2
*Sentrin-specific protease 2
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**[[1tgz]] – hSenp2 catalytic domain + SUMO1<br />
 
**[[1th0]] – hSenp2 catalytic domain <br />
**[[1th0]] – hSenp2 catalytic domain <br />
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**[[1tgz]] – hSenp2 catalytic domain + SUMO1<br />
**[[2io0]], [[5aek]] – hSenp2 catalytic domain (mutant) + SUMO1 precursor<br />
**[[2io0]], [[5aek]] – hSenp2 catalytic domain (mutant) + SUMO1 precursor<br />
**[[3zo5]] - hSenp2 catalytic domain (mutant) + SUMO2 precursor<br />
**[[3zo5]] - hSenp2 catalytic domain (mutant) + SUMO2 precursor<br />
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**[[3eay]] – hSenp7 catalytic domain + SUMO1<br />
**[[3eay]] – hSenp7 catalytic domain + SUMO1<br />
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**[[7r2e]] – hSenp7 catalytic domain + SUMO2<br />
*Sentrin-specific protease 8
*Sentrin-specific protease 8

Current revision

Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry 2iy0)

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3D structures of sentrin-specific protease

Updated on 11-August-2024

References

  1. ↑ Lee WP, Jena S, Doherty D, Ventakesh J, Schimdt J, Furmick J, Widener T, Lemau J, Jurutka PW, Thompson PD. Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling. PLoS One. 2014 Feb 20;9(2):e89506. doi: 10.1371/journal.pone.0089506. eCollection, 2014. PMID:24586832 doi:http://dx.doi.org/10.1371/journal.pone.0089506

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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