Insulin-like growth factor receptor

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<StructureSection load='3i81' size='450' side='right' scene='' caption='Human insulin-like growth factor 1 receptor (PDB code [[3i81]])'>
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<StructureSection load='3i81' size='350' side='right' scene='' caption='Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code [[3i81]])'>
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'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF). IGFR contains 2 extracellular α chains and 2 transmembranal β chains. Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling.
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'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF). IGFR contains 2 extracellular α chains and 2 transmembranal β chains. Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. The insulin-like growth factor 1 (IGF-1) receptor belongs to the large class of [[Receptor tyrosine kinases|tyrosine kinase receptors]]. See also [[IGF1]], [[Growth factors]] and [[Kinase-linked, enzyme-linked and related receptors]].
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=== Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>===
=== Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>===
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*IGFR I
*IGFR I
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**[[1igr]] – hIGFR I domains 1-3 – human<BR />
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**[[1igr]] – hIGFR I domains 1-3 31-492– human<BR />
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**[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) <BR />
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**[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) 983-1286<BR />
**[[1m7n]] - hIGFR I kinase domain<BR />
**[[1m7n]] - hIGFR I kinase domain<BR />
**[[1k3a]] - hIGFR I kinase domain + insulin receptor substrate peptide<BR />
**[[1k3a]] - hIGFR I kinase domain + insulin receptor substrate peptide<BR />
**[[2oj9]], [[2zm3]], [[3d94]], [[3f5p]], [[3i81]], [[3lvp]], [[3nw5]], [[3nw6]], [[3nw7]], [[3lw0]], [[3qqu]], [[3o23]], [[4d2r]], [[5fxq]], [[5fxr]], [[5fxs]], [[5hzn]] - hIGFR I kinase domain + inhibitor<BR />
**[[2oj9]], [[2zm3]], [[3d94]], [[3f5p]], [[3i81]], [[3lvp]], [[3nw5]], [[3nw6]], [[3nw7]], [[3lw0]], [[3qqu]], [[3o23]], [[4d2r]], [[5fxq]], [[5fxr]], [[5fxs]], [[5hzn]] - hIGFR I kinase domain + inhibitor<BR />
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**[[5u8r]] - hIGFR I (mutant) + antibody<BR />
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**[[5u8q]] - hIGFR I (mutant) + IGFI + antibody<BR />
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**[[6pyh]] - hIGFR I + IGFI – Cryo EM<BR />
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**[[6vwg]], [[6vwh]], [[6vwi]], [[6vwj]] - hIGFR I + IGFII – Cryo EM<BR />
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**[[7s8v]] - hIGFR I + insulin receptor – Cryo EM<BR />
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**[[7s0q]] - hIGFR I + insulin receptor + IGF I – Cryo EM<BR />
*IGFR II
*IGFR II
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**[[1syo]], [[1sz0]] - bIGFR II domains 1-3 + mannose-6-phosphate<BR />
**[[1syo]], [[1sz0]] - bIGFR II domains 1-3 + mannose-6-phosphate<BR />
**[[2lla]] - IGFR II domain 11 – short-beaked echidna - NMR<BR />
**[[2lla]] - IGFR II domain 11 – short-beaked echidna - NMR<BR />
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**[[2l2g]] - IGFR II domain 11 – opossum - NMR<BR />
}}
}}
== References ==
== References ==

Current revision

Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code 3i81)

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3D structures of insulin-like growth factor receptor

Updated on 08-June-2023

References

  1. ↑ Hung IC, Chang SS, Chang PC, Lee CC, Chen CY. Memory enhancement by traditional Chinese medicine? J Biomol Struct Dyn. 2012 Dec 19. PMID:23249175 doi:10.1080/07391102.2012.741052

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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