Interferon receptor

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* '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2<ref>PMID:9462485</ref>.<br />
* '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2<ref>PMID:9462485</ref>.<br />
* '''Interferon δ receptor''' binds interferon-δ<ref>PMID:9865499</ref>.
* '''Interferon δ receptor''' binds interferon-δ<ref>PMID:9865499</ref>.
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See also: [[Cytokine receptors]].
== Relevance ==
== Relevance ==
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== Disease ==
== Disease ==
Mutations of interferon γ receptor confer susceptibility to infections caused by mycobacteria<ref>PMID:10192386</ref>.
Mutations of interferon γ receptor confer susceptibility to infections caused by mycobacteria<ref>PMID:10192386</ref>.
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</StructureSection>
 
==3D structures of interferon receptor==
==3D structures of interferon receptor==
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[[Interferon receptor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Interferon α/β receptor
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**[[3s98]] – hINFAR1 ectodomain – human <br />
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**[[1n6u]], [[1n6v]] – hINFAR2 ectodomain - NMR <br />
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**[[3s8w]] – hINFAR2 D2 domain - NMR <br />
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**[[2hym]], [[2kz1]], [[2lag]] – hINFAR2 ectodomain + interferon-α 2 - NMR <br />
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**[[3s9d]] – hINFAR2 ectodomain + interferon-α 2 <br />
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**[[3se3]] – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-α 2 <br />
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**[[3se4]] – hINFAR2 ectodomain + hINFAR1 ectodomain + interferon-ω 1 <br />
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**[[3wcy]] – INFAR1 ectodomain + interferon-β - mouse <br />
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*Interferon γ receptor
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**[[1jrh]] – hINFGR1 N terminal (mutant) + antibody <br />
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**[[1fg9]], [[1fyh]] – hINFGR1 extracellular domain + interferon-γ <br />
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**[[4eq2]], [[4eq3]] – INFGR1 α chain - chicken <br />
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**[[5eh1]] – hINFGR2 extracellular domain <br />
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*Interferon δ receptor
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**[[3og4]], [[3og6]] – hINFDR1 extracellular domain + interleukin-29 <br />
 
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**[[5t5w]] – hINFDR1 extracellular domain + interleukin-10 receptor + interferon-δ 3 <br />
 
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**[[5t5w]], [[5ixd]] – hINFDR1 residues 260-307 + JAK1 <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of interferon α/β receptor β chain ectodomain (yellow) complex with interferon-α 2 (pink) and Cl- ion (green) (PDB entry 3s9d)

Drag the structure with the mouse to rotate

References

  1. ↑ Uze G, Schreiber G, Piehler J, Pellegrini S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007;316:71-95. PMID:17969444
  2. ↑ Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G. The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 1997 Sep;8(3):189-206. PMID:9462485
  3. ↑ Lefevre F, Guillomot M, D'Andrea S, Battegay S, La Bonnardiere C. Interferon-delta: the first member of a novel type I interferon family. Biochimie. 1998 Aug-Sep;80(8-9):779-88. PMID:9865499
  4. ↑ . PMID:16451483
  5. ↑ Santiago-Raber ML, Baccala R, Haraldsson KM, Choubey D, Stewart TA, Kono DH, Theofilopoulos AN. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med. 2003 Mar 17;197(6):777-88. PMID:12642605 doi:http://dx.doi.org/10.1084/jem.20021996
  6. ↑ Jouanguy E, Lamhamedi-Cherradi S, Lammas D, Dorman SE, Fondaneche MC, Dupuis S, Doffinger R, Altare F, Girdlestone J, Emile JF, Ducoulombier H, Edgar D, Clarke J, Oxelius VA, Brai M, Novelli V, Heyne K, Fischer A, Holland SM, Kumararatne DS, Schreiber RD, Casanova JL. A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection. Nat Genet. 1999 Apr;21(4):370-8. PMID:10192386 doi:http://dx.doi.org/10.1038/7701

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