TNF receptor-associated factor

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<StructureSection load='1f3v' size='450' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code [[1f3v]])' scene='70/708054/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code [[1f3v]])' scene='70/708054/Cv/1'>
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__TOC__
== Function ==
== Function ==
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'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>. '''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs. '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK. '''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>. '''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
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'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.
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*'''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs.
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*'''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.
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*'''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>.
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*'''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
== Structural highlights ==
== Structural highlights ==
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The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/3'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
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The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/4'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
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</StructureSection>
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== 3D Structures of TNF receptor-associated factor ==
== 3D Structures of TNF receptor-associated factor ==
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[[TNF receptor-associated factor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*TRAF1
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**[[3m0d]] – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 - human<br />
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*TRAF2
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**[[1ca4]] – hTRAF2 TRAF domain residues 334-501<br />
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**[[3knv]] – hTRAF2 RING+zinc finger 1 domains residues 1-133 <br />
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**[[3m06]] – hTRAF2 residues 266-329 <br />
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*TRAF2 complex with peptide
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**[[1ca9]] – hTRAF2 TRAF domain + TNF-R2 peptide<br />
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**[[1qsc]], [[1d00]], [[1czz]] – hTRAF2 TRAF domain + CD40 receptor peptide<br />
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**[[1d01]] – hTRAF2 TRAF domain + CD30 peptide<br />
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**[[1czy]] – hTRAF2 TRAF domain + latent membrane protein peptide<br />
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**[[1d0a]] – hTRAF2 TRAF domain + OX40L receptor peptide<br />
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**[[1d0j]] – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide<br />
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**[[1f3v]] – hTRAF2 TRAF domain + TRADD N terminal<br />
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**[[3m0a]] – hTRAF2 residues 266-329 + cIAP2<br />
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*TRAF3
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**[[4ghu]] – TRAF3 TRAF domain residues 376-567 + antiviral-signaling protein peptide - mouse <br />
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*TRAF4
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**[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain residues 281-470 <br />
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*TRAF5
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**[[4gjh]] – hTRAF5 TRAF domain residues 381-558 <br />
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*TRAF6
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**[[1lb4]] – hTRAF6 TRAF domain <br />
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**[[2jmd]], [[2eci]] – hTRAF6 RING domain - NMR<br />
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**[[3hcs]] – hTRAF6 RING+zinc finger 1-3 domains <br />
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*TRAF6 complex with peptide
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**[[1lb5]] – hTRAF6 TRAF domain + RANK peptide<br />
 
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**[[1lb6]] – hTRAF6 TRAF domain + CD40 antigen peptide<br />
 
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**[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br />
 
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**[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v)

Drag the structure with the mouse to rotate

References

  1. ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:http://dx.doi.org/10.1038/sj.onc.1204788
  2. ↑ Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:http://dx.doi.org/10.1111/j.1600-065X.2011.01055.x
  3. ↑ Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:http://dx.doi.org/10.1111/j.1538-7836.2010.04091.x
  4. ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

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