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Mannose-binding protein
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='1kzb' size='400' side='right' scene='48/487540/Cv/1' caption='Rat mannose-binding protein fragment complex with mannose and Ca+2 ion, [[1kzb]]'> | + | <StructureSection load='1kzb' size='400' side='right' scene='48/487540/Cv/1' caption='Rat mannose-binding protein fragment complex with mannose and Ca+2 ion (green), [[1kzb]]'> |
== Function == | == Function == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *'''mannose-binding protein''' | + | *'''mannose-binding protein-a''' |
| - | **[[1ytt]], [[1kwt]], [[1nt0]] - rMBL fragment - rat<br /> | ||
| - | **[[1kmb]], [[1fif]] - rMBL fragment (mutant)<br /> | ||
**[[1hup]] – hMBL – human<br /> | **[[1hup]] – hMBL – human<br /> | ||
| + | **[[1ytt]], [[1kwt]], [[1buu]], [[1rtm]] - rMBL fragment - rat<br /> | ||
| + | **[[1kmb]], [[1fif]], [[1afd]], [[2kmb]] - rMBL fragment (mutant)<br /> | ||
| + | **[[1msb]] - rMBL lectin domain<br /> | ||
**[[3a0c]] – PcMBL – ''Polygonatum cyrtonema''<br /> | **[[3a0c]] – PcMBL – ''Polygonatum cyrtonema''<br /> | ||
**[[4akd]] – MBL – ''Artocarpus integer''<br /> | **[[4akd]] – MBL – ''Artocarpus integer''<br /> | ||
| Line 25: | Line 26: | ||
**[[2y1s]] – MaMBL – ''Microcystis aeruginosa'' - NMR<br /> | **[[2y1s]] – MaMBL – ''Microcystis aeruginosa'' - NMR<br /> | ||
| - | *Mannose-binding protein complex with sugar | + | *Mannose-binding protein-a complex with sugar |
**[[1rdi]], [[1rdj]], [[1rdk]], [[1rdl]], [[1rdm]], [[1rdn]], [[1rdo]], [[1kwu]], [[1kwv]], [[1kww]], [[1kwx]] – rMBL fragment + monosaccharide <br /> | **[[1rdi]], [[1rdj]], [[1rdk]], [[1rdl]], [[1rdm]], [[1rdn]], [[1rdo]], [[1kwu]], [[1kwv]], [[1kww]], [[1kwx]] – rMBL fragment + monosaccharide <br /> | ||
| - | **[[1fih]] - rMBL fragment (mutant) + monosaccharide<br /> | + | **[[1fih]], [[1afa]], [[1afb]], [[1bch]], [[1bcj]] - rMBL fragment (mutant) + monosaccharide<br /> |
**[[1kwy]], [[1kx1]], [[1kza]], [[1kzd]], [[1kze]] - rMBL fragment + bisaccharide<br /> | **[[1kwy]], [[1kx1]], [[1kza]], [[1kzd]], [[1kze]] - rMBL fragment + bisaccharide<br /> | ||
**[[1kwz]], [[1kx0]] - rMBL fragment (mutant) + bisaccharide<br /> | **[[1kwz]], [[1kx0]] - rMBL fragment (mutant) + bisaccharide<br /> | ||
**[[1kzb]], [[1kzc]] - rMBL fragment + mannose<br /> | **[[1kzb]], [[1kzc]] - rMBL fragment + mannose<br /> | ||
| + | **[[2msb]] - rMBL fragment + oligosaccharide<br /> | ||
| + | **[[3kmb]], [[4kmb]] - rMBL fragment (mutant) + oligosaccharide<br /> | ||
**[[1qmo]] – MBL + mannose – bean<br /> | **[[1qmo]] – MBL + mannose – bean<br /> | ||
**[[2chh]] – MBL + alpha-mannose + beta-mannose – ''Ralstonia solanacearum''<br /> | **[[2chh]] – MBL + alpha-mannose + beta-mannose – ''Ralstonia solanacearum''<br /> | ||
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**[[1zhs]] – MvMBL + ManGlcNac<br /> | **[[1zhs]] – MvMBL + ManGlcNac<br /> | ||
**[[2yhh]] – MaMBL + alpha-mannose - NMR<br /> | **[[2yhh]] – MaMBL + alpha-mannose - NMR<br /> | ||
| + | |||
| + | *Mannose-binding protein-c | ||
| + | |||
| + | **[[1bvr]] - rMBL subtilisin fragment<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of mannose-binding protein
Updated on 03-September-2020
References
- ↑ Nakagawa T, Ma BY, Uemura K, Oka S, Kawasaki N, Kawasaki T. Role of mannan-binding protein, MBP, in innate immunity. Anticancer Res. 2003 Nov-Dec;23(6a):4467-71. PMID:14666735
- ↑ Carlsson M, Sjoholm AG, Eriksson L, Thiel S, Jensenius JC, Segelmark M, Truedsson L. Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship. Clin Exp Immunol. 2005 Feb;139(2):306-13. PMID:15654829 doi:http://dx.doi.org/10.1111/j.1365-2249.2004.02690.x
- ↑ Turner MW. The role of mannose-binding lectin in health and disease. Mol Immunol. 2003 Nov;40(7):423-9. PMID:14568388
- ↑ Ng KK, Kolatkar AR, Park-Snyder S, Feinberg H, Clark DA, Drickamer K, Weis WI. Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J Biol Chem. 2002 May 3;277(18):16088-95. Epub 2002 Feb 15. PMID:11850428 doi:10.1074/jbc.M200493200
