Tumor necrosis factor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'> |
== Function == | == Function == | ||
| - | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | + | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]]. |
== Relevance == | == Relevance == | ||
TNF is studied as both a target and a therapeutic in malignant diseases<ref>PMID:19343034</ref>. | TNF is studied as both a target and a therapeutic in malignant diseases<ref>PMID:19343034</ref>. | ||
| - | </StructureSection> | ||
| - | == | + | == Structural highlights == |
| + | The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>. | ||
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| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | == 3D Structures of tumor necrosis factor == | |
| - | + | [[Tumor necrosis factor 3D structures]] | |
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| - | *TNF β | ||
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| - | **[[1tnr]] – hTNF + TNF receptor p55 <BR /> | ||
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| - | *TNF | ||
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| - | **[[2vfj]] – hTNF ovarian tumor domain <BR /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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