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Tumor necrosis factor
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene='55/551212/Cv/1'> |
== Function == | == Function == | ||
| - | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). | + | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. '''TNFα''' is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells<ref>PMID:11514191</ref>. '''TNFβ''' is inhibited by interleukin 10. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). See also [[TRAIL]] and [[Molecular Playground/TRAIL]]. |
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/ | + | The biological assembly of human tumor necrosis factor is <scene name='55/551212/Cv/4'>homotetramer</scene> (PDB entry [[2az5]]). <scene name='55/551212/Cv/5'>Inhibitor binding site</scene>. |
| - | </ | + | |
== 3D Structures of tumor necrosis factor == | == 3D Structures of tumor necrosis factor == | ||
| - | + | [[Tumor necrosis factor 3D structures]] | |
| - | + | ||
| - | *TNF α | ||
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| - | **[[1tnf]] – hTNF – human <BR /> | ||
| - | **[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant) <BR /> | ||
| - | **[[2tnf]] – TNF – mouse <BR /> | ||
| - | **[[2az5]] – hTNF + inhibitor <BR /> | ||
| - | **[[3it8]] – hTNF + poxvirus 2L protein <BR /> | ||
| - | **[[3l9j]] – hTNF + antagonist <BR /> | ||
| - | **[[3alq]] – hTNF (mutant) + TNF receptor <BR /> | ||
| - | **[[4g3y]], [[3wd5]] – hTNF + antibody <BR /> | ||
| - | **[[4twt]] – hTNF + peptide <BR /> | ||
| - | |||
| - | *TNF β | ||
| - | |||
| - | **[[1tnr]] – hTNF + TNF receptor p55 <BR /> | ||
| - | |||
| - | *TNF | ||
| - | |||
| - | **[[2vfj]] – hTNF ovarian tumor domain <BR /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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