Aricept Complexed with Acetylcholinesterase (Arabic)
From Proteopedia
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==نتائج== | ==نتائج== | ||
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| - | تظهر الأشعة السينية لهيكلة المركب '''(E2020 – TcAChE)''' أن ال- '''E2020''' له <scene name='1eve/E2020_close_up_with_84_279/13'> | + | تظهر الأشعة السينية لهيكلة المركب '''(E2020 – TcAChE)''' أن ال- '''E2020''' له <scene name='1eve/E2020_close_up_with_84_279/13'>unique orientation</scene> على طول منطقة الموقع النشط في داخل الأستيلكولينستراز ، وبمتد هذا التوافق من موقع فرعي أنيوني <scene name='1eve/E2020_close_up_with_84lbld/7'> (W84) </scene> من الموقع النشط - في الجزء السفلي ، إلى موقع أنيوني خارجي <scene name='1eve/E2020_close_up_with_84_279lbld/5'> (W279) </scene>- في الجزء العلوي ،وذلك من خلال روابط aromatic stacking interactions مع أحماض نكيليوتيدية أروماتية. بالرغم من ذلك لا يتفاعل ال- '''E2020''' بشكل مباشر مع أي من ثالوث الحفاز أو ال-'oxyanion hole' ولكن فقط بشكل <scene name='1eve/E20_interactionshown/8'> indirectly via solvent molecule </scene>.</p> |
==خاتمة== | ==خاتمة== | ||
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Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10368299 10368299] | Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10368299 10368299] | ||
| - | [[ar: | + | [[ar:Aricept_Complexed_with_Acetylcholinesterase (Arabic)]] |
| - | [[ca: | + | [[ca:Aricept_Complexed_with_Acetylcholinesterase (Catalan)]] |
| - | [[cs: | + | [[zh:Aricept_Complexed_with_Acetylcholinesterase (Chinese)]] |
| - | [[de: | + | [[cs:Aricept_Complexed_with_Acetylcholinesterase (Czech)]] |
| - | [[en: | + | [[de:Aricept_Complexed_with_Acetylcholinesterase (German)]] |
| - | [[es: | + | [[en:Aricept_Complexed_with_Acetylcholinesterase]] |
| - | [[fr: | + | [[es:Aricept_Complexed_with_Acetylcholinesterase (Spanish)]] |
| - | [[he: | + | [[fr:Aricept_Complexed_with_Acetylcholinesterase (French)]] |
| - | [[it: | + | [[he:Aricept_Complexed_with_Acetylcholinesterase (Hebrew)]] |
| - | [[ru: | + | [[it:Aricept_Complexed_with_Acetylcholinesterase (Italian)]] |
| - | [[sk: | + | [[ru:Aricept_Complexed_with_Acetylcholinesterase (Russian)]] |
| - | + | [[sk:Aricept_Complexed_with_Acetylcholinesterase (Slovak)]] | |
| - | [[vi: | + | [[vi:Aricept_Complexed_with_Acetylcholinesterase (Vietnamese)]] |
| - | [[ | + | [[tr:Aricept_Complexed_with_Acetylcholinesterase (Turkish)]] |
Current revision
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مراجع
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs., Kryger G, Silman I, Sussman JL, Structure. 1999 Mar 15;7(3):297-307. PMID:10368299
Page seeded by OCA on Thu Nov 8 12:39:55 2007
Proteopedia Page Contributors and Editors (what is this?)
Muneef Ayyash, Jaime Prilusky, Alexander Berchansky, Judy Voet, Joel L. Sussman, Fred Vellieux, Eran Hodis
