Variable lymphocyte receptor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' scene='45/456531/Cv/1' caption='Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) ([[3g3a]]), resolution 2.20Å'> |
'''Variable lymphocyte receptors''' (VLRs) are [[leucine-rich repeat]] (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. <ref>PMID: 17192264</ref> | '''Variable lymphocyte receptors''' (VLRs) are [[leucine-rich repeat]] (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. <ref>PMID: 17192264</ref> | ||
| - | <scene name='45/456531/Cv/ | + | <scene name='45/456531/Cv/3'>Leucines highlighted in magenta</scene>. |
[[Image:3g3a biol unitsurf.png|370px|left|thumb| [[Lamprey Variable Lymphocyte Receptor]] in complex with a protein antigen ([[3g3a]])]] | [[Image:3g3a biol unitsurf.png|370px|left|thumb| [[Lamprey Variable Lymphocyte Receptor]] in complex with a protein antigen ([[3g3a]])]] | ||
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*[[Antibody]] | *[[Antibody]] | ||
*[[Forkhead box protein]] | *[[Forkhead box protein]] | ||
| - | + | ==3D structures of variable lymphocyte receptor== | |
| + | [[Variable lymphocyte receptor 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of variable lymphocyte receptor== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Variable lymphocyte receptor | ||
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| - | **[[3m19]], [[3g39]], [[2r9u]], [[3wo9]], [[4k5u]], [[4k79]] - mlVLR ectodomain – marine lamprey<br /> | ||
| - | **[[3m18]], [[3g3a]] – mlVLR ectodomain + lysozyme<br /> | ||
| - | **[[3g3b]] - mlVLR ectodomain (mutant) + lysozyme<br /> | ||
| - | **[[3e6j]] - mlVLR ectodomain + trisaccharide<br /> | ||
| - | **[[2o6q]], [[2o6r]], [[2o6s]] – IhVLR leucine-rich repeat – inshore hagfish<br /> | ||
| - | **[[3twi]] – VLR B antigen-binding domain + BCLA protein – ''Bacillus anthracis''<br /> | ||
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| - | *Variable lymphocyte receptor chimera | ||
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| - | **[[2z62]], [[2z63]], [[2z66]] – IhVLR/hTLR4<br /> | ||
| - | **[[4qxe]] – IhVLR/G-protein coupled receptor<br /> | ||
| - | **[[4qxf]] – IhVLR/G-protein coupled receptor + r-spondin<br /> | ||
| - | **[[3ul7]], [[3ul8]], [[3ul9]] – IhVLR/hTLR4 (mutant)<br /> | ||
| - | **[[3ula]] – IhVLR/hTLR4 (mutant) + eritoran<br /> | ||
| - | **[[2z80]], [[2z81]], [[2z82]], [[3a78]], [[3a7c]] – IhVLR/hTLR2<br /> | ||
| - | **[[2z65]], [[5ijb]], [[5ijc]], [[5ijd]] – IhVLR/hTLR4 + lymphocyte antigen 96<br /> | ||
| - | **[[2z7x]] – IhVLR/hTLR1 + IhVLR/hTLR2 + tri-acylated lipopeptide<br /> | ||
| - | **[[3a79]] - IhVLR/hTLR2 + IhVLR/hTLR6 + tri-acylated lipopeptide<br /> | ||
| - | **[[3v44]], [[3v47]] - VLR/TLR5B – zebra fish<br /> | ||
| - | **[[4arn]], [[4arr]] - DmVLRB/TLR – ''Drosophila melanogaster''<br /> | ||
| - | **[[4bv4]] - DmVLRB/TLR + spaetzle<br /> | ||
| - | **[[4j4l]] - VLRB/internalin + interleukin-6 – ''Listeria monocytogenes''<br /> | ||
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| - | }} | ||
Articles in Proteopedia concerning Variable lymphocyte receptors include: | Articles in Proteopedia concerning Variable lymphocyte receptors include: | ||
*[[Lamprey Variable Lymphocyte Receptor]] | *[[Lamprey Variable Lymphocyte Receptor]] | ||
Current revision
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Articles in Proteopedia concerning Variable lymphocyte receptors include:
Additional Literature
- Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
- Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
- Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
- Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
- Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
- Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5. Epub 2008 Jan 31. PMID:18238899 doi:10.1073/pnas.0711619105
- Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834
References
- ↑ Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO. Structural diversity of the hagfish variable lymphocyte receptors. J Biol Chem. 2007 Mar 2;282(9):6726-32. Epub 2006 Dec 27. PMID:17192264 doi:10.1074/jbc.M608471200
