5x8q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:55, 22 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.==
==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.==
-
<StructureSection load='5x8q' size='340' side='right' caption='[[5x8q]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+
<StructureSection load='5x8q' size='340' side='right'caption='[[5x8q]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5x8q]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X8Q FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5x8q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X8Q FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=82R:(1R,2S,4S,5R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2-oxane]-10,16-diol'>82R</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x8x|5x8x]], [[5x8w|5x8w]], [[5x8u|5x8u]], [[5x8s|5x8s]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=82R:(1R,2S,4S,5R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2-oxane]-10,16-diol'>82R</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8q OCA], [http://pdbe.org/5x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8q RCSB], [http://www.ebi.ac.uk/pdbsum/5x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8q ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8q OCA], [https://pdbe.org/5x8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x8q RCSB], [https://www.ebi.ac.uk/pdbsum/5x8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
+
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5x8q" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5x8q" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adachi, T]]
+
[[Category: Homo sapiens]]
-
[[Category: Doi, S]]
+
[[Category: Large Structures]]
-
[[Category: Murase, K]]
+
[[Category: Adachi T]]
-
[[Category: Noguchi, M]]
+
[[Category: Doi S]]
-
[[Category: Nomura, A]]
+
[[Category: Murase K]]
-
[[Category: Yamaguchi, K]]
+
[[Category: Noguchi M]]
-
[[Category: Inhibitor]]
+
[[Category: Nomura A]]
-
[[Category: Nuclear receptor]]
+
[[Category: Yamaguchi K]]
-
[[Category: Ternary complex]]
+
-
[[Category: Transferase-ihibitor complex]]
+

Current revision

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.

PDB ID 5x8q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5x8q"
Personal tools