5x8x

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==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.==
==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.==
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<StructureSection load='5x8x' size='340' side='right' caption='[[5x8x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5x8x' size='340' side='right'caption='[[5x8x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5x8x]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X8X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5x8x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X8X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=82O:(3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide'>82O</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x8w|5x8w]], [[5x8u|5x8u]], [[5x8s|5x8s]], [[5x8q|5x8q]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=82O:(3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide'>82O</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8x OCA], [http://pdbe.org/5x8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8x RCSB], [http://www.ebi.ac.uk/pdbsum/5x8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8x ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8x OCA], [https://pdbe.org/5x8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x8x RCSB], [https://www.ebi.ac.uk/pdbsum/5x8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
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[https://www.uniprot.org/uniprot/G1RH57_NOMLE G1RH57_NOMLE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5x8x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5x8x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adachi, T]]
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[[Category: Homo sapiens]]
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[[Category: Doi, S]]
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[[Category: Large Structures]]
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[[Category: Murase, K]]
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[[Category: Adachi T]]
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[[Category: Noguchi, M]]
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[[Category: Doi S]]
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[[Category: Nomura, A]]
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[[Category: Murase K]]
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[[Category: Yamaguchi, K]]
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[[Category: Noguchi M]]
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[[Category: Inhibitor]]
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[[Category: Nomura A]]
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[[Category: Nuclear receptor]]
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[[Category: Yamaguchi K]]
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[[Category: Ternary complex]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.

PDB ID 5x8x

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