This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5x8x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:55, 22 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.==
==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.==
-
<StructureSection load='5x8x' size='340' side='right' caption='[[5x8x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+
<StructureSection load='5x8x' size='340' side='right'caption='[[5x8x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5x8x]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X8X FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5x8x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X8X FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=82O:(3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide'>82O</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x8w|5x8w]], [[5x8u|5x8u]], [[5x8s|5x8s]], [[5x8q|5x8q]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=82O:(3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide'>82O</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8x OCA], [http://pdbe.org/5x8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8x RCSB], [http://www.ebi.ac.uk/pdbsum/5x8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8x ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8x OCA], [https://pdbe.org/5x8x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x8x RCSB], [https://www.ebi.ac.uk/pdbsum/5x8x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
+
[https://www.uniprot.org/uniprot/G1RH57_NOMLE G1RH57_NOMLE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5x8x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5x8x" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Nuclear receptor corepressor|Nuclear receptor corepressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adachi, T]]
+
[[Category: Homo sapiens]]
-
[[Category: Doi, S]]
+
[[Category: Large Structures]]
-
[[Category: Murase, K]]
+
[[Category: Adachi T]]
-
[[Category: Noguchi, M]]
+
[[Category: Doi S]]
-
[[Category: Nomura, A]]
+
[[Category: Murase K]]
-
[[Category: Yamaguchi, K]]
+
[[Category: Noguchi M]]
-
[[Category: Inhibitor]]
+
[[Category: Nomura A]]
-
[[Category: Nuclear receptor]]
+
[[Category: Yamaguchi K]]
-
[[Category: Ternary complex]]
+
-
[[Category: Transferase-inhibitor complex]]
+

Current revision

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.

PDB ID 5x8x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5x8x"
Personal tools