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5eu2

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==Crystal structure of murine neuroglobin mutant V101F at ambient pressure==
==Crystal structure of murine neuroglobin mutant V101F at ambient pressure==
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<StructureSection load='5eu2' size='340' side='right' caption='[[5eu2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5eu2' size='340' side='right'caption='[[5eu2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5eu2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EU2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5eu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EU2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eet|5eet]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eu2 OCA], [http://pdbe.org/5eu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eu2 RCSB], [http://www.ebi.ac.uk/pdbsum/5eu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eu2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eu2 OCA], [https://pdbe.org/5eu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eu2 RCSB], [https://www.ebi.ac.uk/pdbsum/5eu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eu2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>
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[https://www.uniprot.org/uniprot/NGB_MOUSE NGB_MOUSE] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11473111</ref> <ref>PMID:11473128</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5eu2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5eu2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Neuroglobin|Neuroglobin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Girard, E]]
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[[Category: Large Structures]]
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[[Category: Prange, T]]
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[[Category: Mus musculus]]
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[[Category: Vallone, B]]
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[[Category: Colloc'h N]]
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[[Category: H, N Colloc]]
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[[Category: Girard E]]
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[[Category: Globin]]
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[[Category: Prange T]]
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[[Category: Oxygen storage-transporter]]
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[[Category: Vallone B]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of murine neuroglobin mutant V101F at ambient pressure

PDB ID 5eu2

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