5t8u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:56, 4 October 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of P. falciparum LipL1 in complex lipoate==
==Crystal structure of P. falciparum LipL1 in complex lipoate==
-
<StructureSection load='5t8u' size='340' side='right' caption='[[5t8u]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
+
<StructureSection load='5t8u' size='340' side='right'caption='[[5t8u]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5t8u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T8U FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5t8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T8U FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LPA:LIPOIC+ACID'>LPA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.324&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.63 2.7.7.63] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPA:LIPOIC+ACID'>LPA</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t8u OCA], [http://pdbe.org/5t8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t8u RCSB], [http://www.ebi.ac.uk/pdbsum/5t8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t8u ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t8u OCA], [https://pdbe.org/5t8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t8u RCSB], [https://www.ebi.ac.uk/pdbsum/5t8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t8u ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LIPLA_PLAF7 LIPLA_PLAF7] Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (PubMed:17244193, PubMed:25116855, PubMed:28543853). In the mitochondrion, functions as a redox switch between two lipoylation routes (PubMed:25116855). Senses the oxidation state of lipoate and determines which downstream enzymes will be lipoylated (PubMed:25116855). In low reducing conditions, uses lipoate in its oxidized ring form to lipoylate glycine cleavage system H-protein GCVH (PubMed:17244193, PubMed:25116855, PubMed:28543853). In high reducing conditions and together with LipL2, uses reduced lipoate (dihydrolipoate) to lipoylate the E2 component of the branched chain alpha-ketoacid dehydrogenase complex BCKDH-E2/BCDH and the E2 component of the alpha-ketoglutarate dehydrogenase complex KDH. LipL1 is responsible for catalysing the activation of lipoate, forming lipoyl-AMP while LipL2 is required but is not capable of catalyzing this reaction (PubMed:17244193, PubMed:25116855).<ref>PMID:17244193</ref> <ref>PMID:25116855</ref> <ref>PMID:28543853</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Transferase]]
+
[[Category: Large Structures]]
-
[[Category: Afanador, G A]]
+
[[Category: Plasmodium falciparum 3D7]]
-
[[Category: Guerra, A J]]
+
[[Category: Afanador GA]]
-
[[Category: Prigge, S T]]
+
[[Category: Guerra AJ]]
-
[[Category: Ligase]]
+
[[Category: Prigge ST]]
-
[[Category: Lipoylation]]
+

Current revision

Crystal structure of P. falciparum LipL1 in complex lipoate

PDB ID 5t8u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5t8u"
Personal tools