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3alw

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==Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I, MV-H-SLAM(N102H/R108Y) fusion)==
==Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I, MV-H-SLAM(N102H/R108Y) fusion)==
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<StructureSection load='3alw' size='340' side='right' caption='[[3alw]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
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<StructureSection load='3alw' size='340' side='right'caption='[[3alw]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3alw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ALW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3alw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus], [https://en.wikipedia.org/wiki/Saguinus_oedipus Saguinus oedipus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ALW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3alz|3alz]], [[3alx|3alx]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3alw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alw OCA], [http://pdbe.org/3alw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3alw RCSB], [http://www.ebi.ac.uk/pdbsum/3alw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3alw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3alw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alw OCA], [https://pdbe.org/3alw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3alw RCSB], [https://www.ebi.ac.uk/pdbsum/3alw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3alw ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref> [https://www.uniprot.org/uniprot/Q9GJT3_SAGOE Q9GJT3_SAGOE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hashiguchi, T]]
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[[Category: Large Structures]]
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[[Category: Kamishikiryo, J]]
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[[Category: Measles morbillivirus]]
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[[Category: Kubota, M]]
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[[Category: Saguinus oedipus]]
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[[Category: Maenaka, K]]
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[[Category: Synthetic construct]]
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[[Category: Maita, N]]
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[[Category: Hashiguchi T]]
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[[Category: Ose, T]]
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[[Category: Kamishikiryo J]]
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[[Category: Yanagi, Y]]
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[[Category: Kubota M]]
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[[Category: Beta-sandwich]]
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[[Category: Maenaka K]]
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[[Category: Immunoglobulin fold]]
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[[Category: Maita N]]
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[[Category: Six-bladed beta-propeller fold]]
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[[Category: Ose T]]
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[[Category: Viral protein-membrane protein complex]]
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[[Category: Yanagi Y]]
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[[Category: Viral protein-receptor complex]]
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Current revision

Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I, MV-H-SLAM(N102H/R108Y) fusion)

PDB ID 3alw

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