5xvk

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(New page: ==Crystal structure of mouse Nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl Nicotinamide (MNA)== <StructureSection load='5xvk' size='340' side='right' caption='[...)
Current revision (08:15, 22 November 2023) (edit) (undo)
 
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==Crystal structure of mouse Nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl Nicotinamide (MNA)==
==Crystal structure of mouse Nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl Nicotinamide (MNA)==
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<StructureSection load='5xvk' size='340' side='right' caption='[[5xvk]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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<StructureSection load='5xvk' size='340' side='right'caption='[[5xvk]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xvk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XVK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xvk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XVK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8GC:1-methylpyridine-3-carboxamide'>8GC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_N-methyltransferase Nicotinamide N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.1 2.1.1.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8GC:3-carbamoyl-1-methylpyridin-1-ium'>8GC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xvk OCA], [http://pdbe.org/5xvk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xvk RCSB], [http://www.ebi.ac.uk/pdbsum/5xvk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xvk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xvk OCA], [https://pdbe.org/5xvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xvk RCSB], [https://www.ebi.ac.uk/pdbsum/5xvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xvk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NNMT_MOUSE NNMT_MOUSE]] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
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[https://www.uniprot.org/uniprot/NNMT_MOUSE NNMT_MOUSE] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Nicotinamide N-methyltransferase]]
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[[Category: Large Structures]]
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[[Category: Birudukota, S]]
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[[Category: Mus musculus]]
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[[Category: Gosu, R]]
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[[Category: Birudukota S]]
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[[Category: Kandan, S]]
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[[Category: Gosu R]]
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[[Category: Kannt, A]]
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[[Category: Kandan S]]
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[[Category: Parveen, R]]
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[[Category: Kannt A]]
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[[Category: Swaminathan, S]]
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[[Category: Parveen R]]
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[[Category: Thakur, M K]]
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[[Category: Swaminathan S]]
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[[Category: Feedback inhibition]]
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[[Category: Thakur MK]]
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[[Category: Mna]]
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[[Category: Nnmt]]
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[[Category: T2d]]
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[[Category: Ternary complex]]
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[[Category: Transferase]]
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Current revision

Crystal structure of mouse Nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl Nicotinamide (MNA)

PDB ID 5xvk

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