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5xql

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==Crystal structure of a Pseudomonas aeruginosa transcriptional regulator==
==Crystal structure of a Pseudomonas aeruginosa transcriptional regulator==
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<StructureSection load='5xql' size='340' side='right' caption='[[5xql]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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<StructureSection load='5xql' size='340' side='right'caption='[[5xql]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XQL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XQL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.494&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xql OCA], [http://pdbe.org/5xql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xql RCSB], [http://www.ebi.ac.uk/pdbsum/5xql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xql ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xql OCA], [https://pdbe.org/5xql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xql RCSB], [https://www.ebi.ac.uk/pdbsum/5xql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xql ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9HUT5_PSEAE Q9HUT5_PSEAE]
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The transcriptional regulator BrlR is a member of the MerR family of multidrug transport activators in Pseudomonas aeruginosa. Recent study indicates that BrlR is a novel 3',5'-cyclic diguanylic acid (c-di-GMP) receptor and can be activated by c-di-GMP. To gain insight into BrlR function, we determined the structure of BrlR with c-di-GMP complex structure to 2.5 A. The structure and size exclusion chromatography (SEC) data revealed BrlR forms a tetramer and each BrlR protomer consists of three parts, DNA-binding domain, a coiled-coil region and GyrI-like domain. There are two different c-di-GMP binding sites located mainly at the DNA binding domain of each BrlR protomer and do not overlap with the GyrI-like domain. The drug-binding pocket in GyrI-like domain is much conserved indicating it can also bind flat-shaped molecules like other multidrug resistance (MDR) proteins.
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Crystal structure of BrlR with c-di-GMP.,Raju H, Sharma R Biochem Biophys Res Commun. 2017 Aug 19;490(2):260-264. doi:, 10.1016/j.bbrc.2017.06.033. Epub 2017 Jun 12. PMID:28619510<ref>PMID:28619510</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5xql" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Raju, H]]
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[[Category: Large Structures]]
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[[Category: Sharma, R]]
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Transcription]]
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[[Category: Raju H]]
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[[Category: Transcriptional regulator]]
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[[Category: Sharma R]]

Current revision

Crystal structure of a Pseudomonas aeruginosa transcriptional regulator

PDB ID 5xql

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