5vy6

<StructureSection load='5vy6' size='340' side='right' caption='[[5vy6]], [[Resolution|resolution]] 3.06&Aring;' scene=''>

<table><tr><td colspan='2'>[[5vy6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VY6 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vy7|5vy7]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vy6 OCA], [http://pdbe.org/5vy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vy6 RCSB], [http://www.ebi.ac.uk/pdbsum/5vy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vy6 ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The foundational goal of structural DNA nanotechnology-the field that uses oligonucleotides as a molecular building block for the programmable self-assembly of nanostructured systems-was to use DNA to construct three-dimensional (3D) lattices for solving macromolecular structures. The programmable nature of DNA makes it an ideal system for rationally constructing self-assembled crystals and immobilizing guest molecules in a repeating 3D array through their specific stereospatial interactions with the scaffold. In this work, we have extended a previously described motif (4 x 5) by expanding the structure to a system that links four double-helical layers; we use a central weaving oligonucleotide containing a sequence of four six-base repeats (4 x 6), forming a matrix of layers that are organized and dictated by a series of Holliday junctions. In addition, we have assembled mirror image crystals (l-DNA) with the identical sequence that are completely resistant to nucleases. Bromine and selenium derivatives were obtained for the l- and d-DNA forms, respectively, allowing phase determination for both forms and solution of the resulting structures to 3.0 and 3.05 A resolution. Both right- and left-handed forms crystallized in the trigonal space groups with mirror image 3-fold helical screw axes P32 and P31 for each motif, respectively. The structures reveal a highly organized array of discrete and well-defined cavities that are suitable for hosting guest molecules and allow us to dictate a priori the assembly of guest-DNA conjugates with a specified crystalline hand.

Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals.,Simmons CR, Zhang F, MacCulloch T, Fahmi N, Stephanopoulos N, Liu Y, Seeman NC, Yan H J Am Chem Soc. 2017 Aug 2. doi: 10.1021/jacs.7b06485. PMID:28731332<ref>PMID:28731332</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 5vy6" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Simmons, C R]]

[[Category: Yan, H]]

[[Category: Dna]]

[[Category: Dna nanotechnology]]

[[Category: Self-assembly]]