Alpha-lactalbumin

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<StructureSection load='1hml' size='350' side='right' caption='Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions (PDB code [[1hml]]).' scene='46/468232/Cv/1'>
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<StructureSection load='1hml' size='350' side='right' caption='Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions (PDB code [[1hml]]).' scene='46/468232/Cv/1' pspeed='8'>
== Function ==
== Function ==
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'''Alpha-lactalbumin''' (LCA) is the albumin contained in milk and obtained from whey<ref>PMID:10818224</ref>. LCA is the regulatory subunit of the lactose synthase heterodimer which produces lactose by transferring galactose moieties to glucose.
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'''Alpha-lactalbumin''' (LCA) is the albumin contained in milk and obtained from whey<ref>PMID:10818224</ref>. LCA is the regulatory subunit of the '''lactose synthase''' heterodimer which produces lactose by transferring galactose moieties to glucose.
== Relevance ==
== Relevance ==
LCA is tested as a target for potential breast cancer vaccine. LCA is the major whey protein of cow and sheep milk. LCA is the target of testing for the presence of milk as an allergen.
LCA is tested as a target for potential breast cancer vaccine. LCA is the major whey protein of cow and sheep milk. LCA is the target of testing for the presence of milk as an allergen.
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== Structural highlights ==
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*<scene name='46/468232/Cv/4'>Ca coordination site</scene>. Water molecules shown as red spheres.
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*<scene name='46/468232/Cv/5'>Zn coordination site</scene>.
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</StructureSection>
 
== 3D Structures of α-lactalbumin ==
== 3D Structures of α-lactalbumin ==
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[[Alpha-lactalbumin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*α-lactalbumin
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**[[1alc]] – LCA – baboon
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**[[1hml]], [[1b9o]], [[3b0i]], [[3b0o]] – hLCA –human
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**[[1a4v]] – hLCA Ca-binding domain<br />
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**[[1cb3]] – hLCA residues 1-13 - NMR<br />
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**[[1hfx]] – LCA – guinea pig
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**[[1hfy]], [[3b0k]] – gLCA – goat
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**[[1hmk]], [[1fkq]], [[1fkv]] – gLCA (mutant)
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**[[1f6r]], [[1f6s]], [[2g4n]] – bLCA - bovine
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**[[1hfz]] – bLCA (mutant)
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*α-LCA complexes
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**[[1nf5]] – mLCA + β-1,4-galactosyl transferase + glucose – mouse
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**[[1nhe]] – mLCA + β-1,4-galactosyl transferase + UDP
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**[[1nkh]] – mLCA + β-1,4-galactosyl transferase + UDP + Mn
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**[[1nmm]] – mLCA + β-1,4-galactosyl transferase (mutant)
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**[[1nqi]] - mLCA + β-1,4-galactosyl transferase
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**[[1nwg]] - mLCA + β-1,4-galactosyl transferase + butanoyl-glucosamine
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**[[1o23]] - mLCA + β-1,4-galactosyl transferase + UDP-glucose
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**[[1oqm]] - mLCA + β-1,4-galactosyl transferase + UDP-acetyl-galactosamine
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**[[1pzy]] - mLCA (mutant) + β-1,4-galactosyl transferase + acetyl-glucosamine + UDP + Mn
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**[[1yro]] - mLCA + β-1,4-galactosyl transferase + UDP-galactose + Mn
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**[[1fyc]] - mLCA (mutant) + β-1,4-galactosyl transferase + UDP-galactose + Ca
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**[[2fyd]], [[2fyc]] - mLCA (mutant) + β-1,4-galactosyl transferase + glucose + UDP-acetylgalactosamine + Mn<br />
 
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**[[4l41]] - hLCA + β-1,4-galactosyl transferase (mutant)<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions (PDB code 1hml).

Drag the structure with the mouse to rotate

References

  1. ↑ Permyakov EA, Berliner LJ. alpha-Lactalbumin: structure and function. FEBS Lett. 2000 May 19;473(3):269-74. PMID:10818224

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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