This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5khm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:01, 27 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner==
==The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner==
-
<StructureSection load='5khm' size='340' side='right' caption='[[5khm]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
+
<StructureSection load='5khm' size='340' side='right'caption='[[5khm]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5khm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KHM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5khm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KHM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XNH:(3~{R})-4-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PIPERIDIN-4-YL]PHENOXY]ETHYL]-1,3-DIMETHYL-PIPERAZIN-2-ONE'>XNH</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5khm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khm OCA], [http://pdbe.org/5khm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khm RCSB], [http://www.ebi.ac.uk/pdbsum/5khm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khm ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XNH:(3~{R})-4-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PIPERIDIN-4-YL]PHENOXY]ETHYL]-1,3-DIMETHYL-PIPERAZIN-2-ONE'>XNH</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5khm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khm OCA], [https://pdbe.org/5khm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5khm RCSB], [https://www.ebi.ac.uk/pdbsum/5khm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5khm ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 23:
==See Also==
==See Also==
-
*[[Bromodomain-containing protein|Bromodomain-containing protein]]
+
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Patel, J]]
+
[[Category: Homo sapiens]]
-
[[Category: Bromodomain]]
+
[[Category: Large Structures]]
-
[[Category: Transcription factor]]
+
[[Category: Patel J]]

Current revision

The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner

PDB ID 5khm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5khm"
Personal tools