NEDD8
From Proteopedia
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| - | <StructureSection load='1ndd' size='350' side='right' scene='42/420012/Cv/ | + | <StructureSection load='1ndd' size='350' side='right' scene='42/420012/Cv/5' caption='Human NEDD8 complex with sulfate and Cl- (green) ions, [[1ndd]]' pspeed='8'> |
| - | [[NEDD8]] is a ubiquitin-like protein in humans. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase<ref>PMID:15180522</ref>. In yeast the protein is called '''Rub1'''. | + | [[NEDD8]] is a ubiquitin-like protein in humans. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase<ref>PMID:15180522</ref>. In yeast the protein is called '''Rub1'''. |
| + | *<scene name='42/420012/Cv/4'>Cl coordination site is located between 2 monomers</scene>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of NEDD8 == | == 3D Structures of NEDD8 == | ||
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**[[4fbj]] – hNEDD8 + bacterial effector CIF<br /> | **[[4fbj]] – hNEDD8 + bacterial effector CIF<br /> | ||
**[[4p5o]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + DCN1-like protein + UBC12<br /> | **[[4p5o]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + DCN1-like protein + UBC12<br /> | ||
| + | **[[7oni]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + ring-box protein – Cryo EM<br /> | ||
| + | **[[7b5n]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + polyubiquitin – Cryo EM<br /> | ||
| + | **[[7b5l]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + polyubiquitin + S-phase kinase-associated protein + CKS-1 – Cryo EM<br /> | ||
| + | **[[6ttu]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + F-box/WD repeat containing protein + S-phase kinase-associated protein – Cryo EM<br /> | ||
| + | **[[6r7f]] – hNEDD8 in signalosome – Cryo EM<br /> | ||
* Rub1 | * Rub1 | ||
Current revision
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3D Structures of NEDD8
Updated on 17-November-2021
References
- ↑ Chiba T, Tanaka K. Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system. Curr Protein Pept Sci. 2004 Jun;5(3):177-84. PMID:15180522
