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5d69

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==Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-iodoindol-3-yl)acrylic acid) bound==
==Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-iodoindol-3-yl)acrylic acid) bound==
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<StructureSection load='5d69' size='340' side='right' caption='[[5d69]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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<StructureSection load='5d69' size='340' side='right'caption='[[5d69]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5d69]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D69 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D69 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5d69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D69 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=57T:(2E,2Z)-2,2-DISULFANEDIYLBIS[3-(4-IODOPHENYL)PROP-2-ENOIC+ACID]'>57T</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d69 OCA], [http://pdbe.org/5d69 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d69 RCSB], [http://www.ebi.ac.uk/pdbsum/5d69 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d69 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=57T:(2E,2Z)-2,2-DISULFANEDIYLBIS[3-(4-IODOPHENYL)PROP-2-ENOIC+ACID]'>57T</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d69 OCA], [https://pdbe.org/5d69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d69 RCSB], [https://www.ebi.ac.uk/pdbsum/5d69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d69 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CPNS1_HUMAN CPNS1_HUMAN]] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
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[https://www.uniprot.org/uniprot/CPNS1_HUMAN CPNS1_HUMAN] Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Calpain|Calpain]]
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*[[Calpain 3D structures|Calpain 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adams, S E]]
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[[Category: Homo sapiens]]
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[[Category: Allemann, R K]]
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[[Category: Large Structures]]
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[[Category: Hallett, M B]]
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[[Category: Adams SE]]
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[[Category: Miller, D J]]
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[[Category: Allemann RK]]
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[[Category: Rizkallah, P J]]
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[[Category: Hallett MB]]
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[[Category: Robinson, E J]]
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[[Category: Miller DJ]]
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[[Category: Calcium binding domain]]
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[[Category: Rizkallah PJ]]
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[[Category: Cysteine protease]]
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[[Category: Robinson EJ]]
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[[Category: Domain vi]]
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[[Category: Hydrolase]]
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[[Category: Mercaptoacrylic acid]]
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Current revision

Human calpain PEF(S) with (2Z,2Z')-2,2'-disulfanediylbis(3-(6-iodoindol-3-yl)acrylic acid) bound

PDB ID 5d69

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