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5cs2

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==Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A==
==Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A==
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<StructureSection load='5cs2' size='340' side='right' caption='[[5cs2]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='5cs2' size='340' side='right'caption='[[5cs2]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7] and [https://en.wikipedia.org/wiki/Streptomyces Streptomyces]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CS2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=54C:(BETAR)-BETA-HYDROXY-1-{2-[(2R)-OXIRAN-2-YL]PROPAN-2-YL}-L-TRYPTOPHAN'>54C</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=WLU:(4R)-5-HYDROXY-N-METHYL-L-LEUCINE'>WLU</scene>, <scene name='pdbligand=WPA:(BETAR)-BETA-METHOXY-L-PHENYLALANINE'>WPA</scene>, <scene name='pdbligand=WVL:(2S,3R)-2-AMINO-3,5-DIMETHYLHEX-4-ENOIC+ACID'>WVL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [http://pdbe.org/5cs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs2 OCA], [https://pdbe.org/5cs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cs2 RCSB], [https://www.ebi.ac.uk/pdbsum/5cs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8IL97_PLAF7 Q8IL97_PLAF7]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum 3D7]]
[[Category: Streptomyces]]
[[Category: Streptomyces]]
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[[Category: Delmas, C]]
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[[Category: Delmas C]]
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[[Category: Gerhartz, B]]
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[[Category: Gerhartz B]]
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[[Category: Hinniger, A]]
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[[Category: Hinniger A]]
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[[Category: Ostermann, N]]
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[[Category: Ostermann N]]
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[[Category: Schmitt, E]]
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[[Category: Schmitt E]]
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[[Category: Anti-plasmodial activity]]
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[[Category: Cyclomarin some]]
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[[Category: Diadenosine triphosphate hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Malaria]]
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[[Category: Plasmodium falciparum]]
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Current revision

Crystal structure of Plasmodium falciparum diadenosine triphosphate hydrolase in complex with Cyclomarin A

PDB ID 5cs2

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