5e9v

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==Crystal structure of BRD9 bromodomain in complex with an indolizine ligand==
==Crystal structure of BRD9 bromodomain in complex with an indolizine ligand==
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<StructureSection load='5e9v' size='340' side='right' caption='[[5e9v]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5e9v' size='340' side='right'caption='[[5e9v]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5e9v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E9V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5e9v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E9V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5L0:1-[1-(IMIDAZO[1,2-A]PYRIDIN-5-YL)-7-(MORPHOLIN-4-YL)INDOLIZIN-3-YL]ETHANONE'>5L0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e9v OCA], [http://pdbe.org/5e9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e9v RCSB], [http://www.ebi.ac.uk/pdbsum/5e9v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e9v ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5L0:1-[1-(IMIDAZO[1,2-A]PYRIDIN-5-YL)-7-(MORPHOLIN-4-YL)INDOLIZIN-3-YL]ETHANONE'>5L0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e9v OCA], [https://pdbe.org/5e9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e9v RCSB], [https://www.ebi.ac.uk/pdbsum/5e9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e9v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.
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[https://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN] May play a role in chromatin remodeling and regulation of transcription.
==See Also==
==See Also==
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*[[Bromodomain-containing protein|Bromodomain-containing protein]]
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Brennan, P E]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: Brennan PE]]
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[[Category: Fedorov, O]]
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[[Category: Edwards AM]]
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[[Category: Hay, D A]]
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[[Category: Fedorov O]]
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[[Category: Knapp, S]]
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[[Category: Hay DA]]
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[[Category: Krojer, T]]
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[[Category: Knapp S]]
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[[Category: Nunez-Alonso, G]]
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[[Category: Krojer T]]
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[[Category: Picaud, S]]
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[[Category: Nunez-Alonso G]]
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[[Category: Schofield, C J]]
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[[Category: Picaud S]]
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[[Category: Tallant, C]]
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[[Category: Schofield CJ]]
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[[Category: Bromodomain]]
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[[Category: Tallant C]]
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[[Category: Chromatin regulation]]
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[[Category: Von Delft F]]
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[[Category: Transcription]]
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Current revision

Crystal structure of BRD9 bromodomain in complex with an indolizine ligand

PDB ID 5e9v

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