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Neuropilin
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' scene='46/466529/Cv/1' caption='Human glycosylated neuropilin-1 domains A2,B1,B2 complex with ethylene glycol and Ca+2 ion (green) [[2qqm]]'> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region. | NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region. | ||
| - | *<scene name='46/466529/Cv/ | + | *<scene name='46/466529/Cv/3'>Ca coordination site</scene>. Water molecule are shown as red sphere. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of Neuropilin == | == 3D Structures of Neuropilin == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *NRP-1 | + | *NRP-1; Domains - B1 273-427, MAM 628-813, A2B1B2 141-586 |
**[[1kex]], [[2qqi]] – hNRP-1 B1 domain – human<br /> | **[[1kex]], [[2qqi]] – hNRP-1 B1 domain – human<br /> | ||
**[[4rn5]] – hNRP-1 B1 domain<br /> | **[[4rn5]] – hNRP-1 B1 domain<br /> | ||
| + | **[[7o1n]] – hNRP-1 B1 domain (mutant)<br /> | ||
**[[5l73]] – hNRP-1 MAM domain<br /> | **[[5l73]] – hNRP-1 MAM domain<br /> | ||
| - | |||
**[[2qqm]] - hNRP-1 A2+B1+B2 domains<br /> | **[[2qqm]] - hNRP-1 A2+B1+B2 domains<br /> | ||
**[[4deq]] - hNRP-1 B1 domain + VEGF-A heparin-binding domain<br /> | **[[4deq]] - hNRP-1 B1 domain + VEGF-A heparin-binding domain<br /> | ||
| + | **[[6tkk]] - hNRP-1 B1 domain + VEGF-A peptide<br /> | ||
| + | **[[7p5u]] - hNRP-1 B1 domain + VEGF-B peptide<br /> | ||
| + | **[[7jjc]] - hNRP-1 B1 domain + SARS-CoV-2 peptide<br /> | ||
**[[2qqn]] - hNRP-1 B1 domain + VEGF-blocking antibody | **[[2qqn]] - hNRP-1 B1 domain + VEGF-blocking antibody | ||
**[[5c7g]] – hNRP-1 B1 domain + bicine<br /> | **[[5c7g]] – hNRP-1 B1 domain + bicine<br /> | ||
**[[5ijr]], [[5iyy]], [[5j1x]], [[5jgi]], [[5jgq]], [[5jhk]] – hNRP-1 B1 domain + arginine derivative<br /> | **[[5ijr]], [[5iyy]], [[5j1x]], [[5jgi]], [[5jgq]], [[5jhk]] – hNRP-1 B1 domain + arginine derivative<br /> | ||
| - | **[[3i97]] - hNRP-1 B1 domains + inhibitor | + | **[[3i97]], [[6fmc]], [[6fmf]] - hNRP-1 B1 domains + inhibitor |
**[[2orx]] – rNRP-1 B domains – rat | **[[2orx]] – rNRP-1 B domains – rat | ||
**[[2orz]] – rNRP-1 B domains + tuftsin peptide<br /> | **[[2orz]] – rNRP-1 B domains + tuftsin peptide<br /> | ||
| - | **[[4gz9]] - mNRP-1 | + | **[[4gz9]] - mNRP-1 – mouse<br /> |
| - | **[[4gza]] - mNRP-1 | + | **[[4gza]] - mNRP-1 + plexin A2 + semaphorin 3A<br /> |
| + | **[[7m0r]] – mNRP-1 + Semaphorin 3A + plexin A4 – Cryo EM<br /> | ||
| - | *NRP-2 | + | *NRP-2; Domains - CUB 27-145; A2 145-275; B1 275-430; B2 431-595 |
| + | **[[7t4s]] – hNRP-2 + Herpes virus envelope + antibody – Cryo EM<br /> | ||
**[[4qdq]], [[4qds]], [[2qqj]] - hNRP-2 B1+B2 domains<br /> | **[[4qdq]], [[4qds]], [[2qqj]] - hNRP-2 B1+B2 domains<br /> | ||
**[[5dq0]] – hNRP-2 B1 domain<br /> | **[[5dq0]] – hNRP-2 B1 domain<br /> | ||
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**[[2qqo]] - hNRP-2 A2+B1+B2 domains | **[[2qqo]] - hNRP-2 A2+B1+B2 domains | ||
| - | **[[2qqk]], [[2qql]] - hNRP-2 | + | **[[2qqk]], [[2qql]] - hNRP-2 A2+B1+B2 domains + semaphorin-blocking antibody<br /> |
| - | **[[5dn2]] – hNRP-2 B1 domain + VEGF-A C terminal<br /> | + | **[[5dn2]], [[6tdb]], [[6tjt]] – hNRP-2 B1 domain + VEGF-A C terminal<br /> |
| + | **[[6gh8]] – hNRP-2 CUB domain 1 + Gp1<br /> | ||
| + | **[[7m22]] – mNRP-2 + cytomegalovirus – Cryo EM<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Neuropilin
Updated on 16-July-2023
References
- ↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
- ↑ Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639. PMID:18363553 doi:http://dx.doi.org/10.1042/BJ20071639
