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5uj6

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==Crystal Structure of Bacteroides Uniformis beta-glucuronidase==
==Crystal Structure of Bacteroides Uniformis beta-glucuronidase==
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<StructureSection load='5uj6' size='340' side='right' caption='[[5uj6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5uj6' size='340' side='right'caption='[[5uj6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uj6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UJ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uj6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_uniformis_str._3978_T3_ii Bacteroides uniformis str. 3978 T3 ii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UJ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj6 OCA], [http://pdbe.org/5uj6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uj6 RCSB], [http://www.ebi.ac.uk/pdbsum/5uj6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj6 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uj6 OCA], [https://pdbe.org/5uj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uj6 RCSB], [https://www.ebi.ac.uk/pdbsum/5uj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uj6 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A078SUX9_BACUN A0A078SUX9_BACUN]
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Microbiome-encoded beta-glucuronidase (GUS) enzymes play important roles in human health by metabolizing drugs in the gastrointestinal (GI) tract. The numbers, types, and diversity of these proteins in the human GI microbiome, however, remain undefined. We present an atlas of GUS enzymes comprehensive for the Human Microbiome Project GI database. We identify 3,013 total and 279 unique microbiome-encoded GUS proteins clustered into six unique structural categories. We assign their taxonomy, assess cellular localization, reveal the inter-individual variability within the 139 individuals sampled, and discover 112 novel microbial GUS enzymes. A representative in vitro panel of the most common GUS proteins by read abundances highlights structural and functional variabilities within the family, including their differential processing of smaller glucuronides and larger carbohydrates. These data provide a sequencing-to-molecular roadmap for examining microbiome-encoded enzymes essential to human health.
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An Atlas of beta-Glucuronidases in the Human Intestinal Microbiome.,Pollet RM, D'Agostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN, Bahethi RR, Bhatt AP, Liu J, Gharaibeh RZ, Redinbo MR Structure. 2017 Jul 5;25(7):967-977.e5. doi: 10.1016/j.str.2017.05.003. Epub 2017, Jun 1. PMID:28578872<ref>PMID:28578872</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5uj6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Redinbo, M R]]
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[[Category: Bacteroides uniformis str. 3978 T3 ii]]
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[[Category: Walton, W G]]
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[[Category: Large Structures]]
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[[Category: Glucuronic-acid carbohydrate]]
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[[Category: Redinbo MR]]
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[[Category: Hydrolase]]
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[[Category: Walton WG]]

Current revision

Crystal Structure of Bacteroides Uniformis beta-glucuronidase

PDB ID 5uj6

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