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5vod

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==Crystal structure of HCMV Pentamer in complex with neutralizing antibody 9I6==
==Crystal structure of HCMV Pentamer in complex with neutralizing antibody 9I6==
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<StructureSection load='5vod' size='340' side='right' caption='[[5vod]], [[Resolution|resolution]] 5.90&Aring;' scene=''>
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<StructureSection load='5vod' size='340' side='right'caption='[[5vod]], [[Resolution|resolution]] 5.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vod]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VOD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vod]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_5508 Human herpesvirus 5 strain 5508], [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169] and [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_Merlin Human herpesvirus 5 strain Merlin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VOD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 5.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cob|5cob]], [[5voc|5voc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vod OCA], [http://pdbe.org/5vod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vod RCSB], [http://www.ebi.ac.uk/pdbsum/5vod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vod ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vod OCA], [https://pdbe.org/5vod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vod RCSB], [https://www.ebi.ac.uk/pdbsum/5vod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vod ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GL_HCMV8 GL_HCMV8]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. [[http://www.uniprot.org/uniprot/GH_HCMVM GH_HCMVM]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. [[http://www.uniprot.org/uniprot/U131A_HCMVM U131A_HCMVM]] Plays an essential role in endothelial cell entry and release steps. Contributes to the formation of the complex between UL128, UL130 and gH-gL.<ref>PMID:16894182</ref> <ref>PMID:22031943</ref>
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[https://www.uniprot.org/uniprot/GH_HCMVM GH_HCMVM] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chandramouli, S]]
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[[Category: Homo sapiens]]
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[[Category: Malito, E]]
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[[Category: Human herpesvirus 5 strain 5508]]
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[[Category: Hcmv]]
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[[Category: Human herpesvirus 5 strain AD169]]
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[[Category: Immune system]]
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[[Category: Human herpesvirus 5 strain Merlin]]
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[[Category: Immunogen]]
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[[Category: Large Structures]]
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[[Category: Neutralizing epitope]]
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[[Category: Chandramouli S]]
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[[Category: Pentamer]]
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[[Category: Malito E]]
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[[Category: Vaccine]]
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[[Category: Viral entry]]
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[[Category: Viral protein-immune system complex]]
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Current revision

Crystal structure of HCMV Pentamer in complex with neutralizing antibody 9I6

PDB ID 5vod

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