Phage integrase
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| - | <StructureSection load=' | + | <StructureSection load='' size='400' side='right' scene='44/443479/Cv/2' caption='Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) [[1z1g]]' pspeed='8'> |
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'''Phage integrase''' (PIN) mediates recombination between DNA recognition sequences - the phage attachment site attP and the bacterial attachment site attB<ref>PMID:14687564</ref>. The '''Tyrosine family PIN''' uses a catalytic tyrosine to mediate strand cleavage while the '''Serine family PIN''' uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria. | '''Phage integrase''' (PIN) mediates recombination between DNA recognition sequences - the phage attachment site attP and the bacterial attachment site attB<ref>PMID:14687564</ref>. The '''Tyrosine family PIN''' uses a catalytic tyrosine to mediate strand cleavage while the '''Serine family PIN''' uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria. | ||
| + | *The biological assembly of Enterobacteria phage λ integrase is <scene name='44/443479/Cv/3'>homotetramer</scene>. | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of phage integrase == | + | == 3D Structures of phage integrase see [[Retroviral Integrase]]== |
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| - | [[3nrw]] – PIN/site-specific recombinase N-terminal – ''Haloarcula marismortui''<br /> | ||
| - | [[3jtz]] – PIN arm-type binding domain – ''Yersinia pestis''<br /> | ||
| - | [[3ju0]] – HPI PIN arm-type binding domain – ''Pectobacterium atrosepticum''<br /> | ||
| - | [[2kkp]] – PIN SAM-like domain – ''Moorella thermoacetica'' – NMR<br /> | ||
| - | [[2kkv]] – PIN fragment – ''Salmonella enterica'' – NMR<br /> | ||
| - | [[2khq]] - PIN fragment – ''Staphylococcus saprophyticus'' – NMR<br /> | ||
| - | [[2wcc]] – λPIN DBD+ DNA – Enterobacteria phage λ - NMR<br /> | ||
| - | [[1kjk]] – λPIN N-terminal - NMR<br /> | ||
| - | [[2oxo]], [[1z19]], [[1z1b]] - λPIN core binding domain + DNA<br /> | ||
| - | [[1ae9]] - λPIN catalytic core domain (mutant) <br /> | ||
| - | [[1z1g]] – λPIN + DNA (Holliday junction)<br /> | ||
| - | [[1p7d]] – λPIN fragment + DNA <br /> | ||
| - | [[3bvp]] – PIN catalytic core domain – Lactococcus phage TP101-1<br /> | ||
| - | [[1aih]] - PIN catalytic core domain – Haemophilus phage HP1<br /> | ||
| - | [[2khv]], [[2kj5]] – PIN residues 102-199 – ''Nitrosospira multiformis'' - NMR | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of phage integrase see Retroviral Integrase
References
- ↑ Groth AC, Calos MP. Phage integrases: biology and applications. J Mol Biol. 2004 Jan 16;335(3):667-78. PMID:14687564 doi:http://dx.doi.org/10.1016/S0022283603013561
