5xnx

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(New page: ==Crystallographic structure of the enzymatically active N-terminal domain of the Rel protein from Mycobacterium tuberculosis== <StructureSection load='5xnx' size='340' side='right' capti...)
Current revision (08:07, 22 November 2023) (edit) (undo)
 
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==Crystallographic structure of the enzymatically active N-terminal domain of the Rel protein from Mycobacterium tuberculosis==
==Crystallographic structure of the enzymatically active N-terminal domain of the Rel protein from Mycobacterium tuberculosis==
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<StructureSection load='5xnx' size='340' side='right' caption='[[5xnx]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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<StructureSection load='5xnx' size='340' side='right'caption='[[5xnx]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xnx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XNX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xnx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XNX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnx OCA], [http://pdbe.org/5xnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xnx RCSB], [http://www.ebi.ac.uk/pdbsum/5xnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnx ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnx OCA], [https://pdbe.org/5xnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xnx RCSB], [https://www.ebi.ac.uk/pdbsum/5xnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RELA_MYCTU RELA_MYCTU]] In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp, which is then hydrolyzed to form ppGpp, as well as the hydrolysis of ppGpp. RelA is probably a key factor in the pathogenesis of M.tuberculosis as it regulates the intracellular concentrations of (p)ppGpp.<ref>PMID:10375643</ref> <ref>PMID:10940033</ref>
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[https://www.uniprot.org/uniprot/RELA_MYCTU RELA_MYCTU] In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp, which is then hydrolyzed to form ppGpp, as well as the hydrolysis of ppGpp. RelA is probably a key factor in the pathogenesis of M.tuberculosis as it regulates the intracellular concentrations of (p)ppGpp.<ref>PMID:10375643</ref> <ref>PMID:10940033</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Balakrishna, A M]]
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[[Category: Large Structures]]
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[[Category: Gruber, G]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Manimekalai, M S.S]]
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[[Category: Balakrishna AM]]
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[[Category: Nartey, W]]
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[[Category: Gruber G]]
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[[Category: Singal, B]]
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[[Category: Manimekalai MSS]]
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[[Category: Hd domain]]
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[[Category: Nartey W]]
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[[Category: Helix bundle]]
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[[Category: Singal B]]
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[[Category: Hydrolase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Rela]]
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[[Category: Stringent response]]
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[[Category: Synthetase domain]]
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[[Category: Transferase]]
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Current revision

Crystallographic structure of the enzymatically active N-terminal domain of the Rel protein from Mycobacterium tuberculosis

PDB ID 5xnx

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