This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1wes

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:35, 9 May 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1wes.jpg|left|200px]]
 
-
{{Structure
+
==Solution structure of PHD domain in inhibitor of growth family, member 1-like==
-
|PDB= 1wes |SIZE=350|CAPTION= <scene name='initialview01'>1wes</scene>
+
<StructureSection load='1wes' size='340' side='right'caption='[[1wes]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[1wes]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WES FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= RIKEN cDNA 2810011M06 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wes OCA], [https://pdbe.org/1wes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wes RCSB], [https://www.ebi.ac.uk/pdbsum/1wes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wes ProSAT], [https://www.topsan.org/Proteins/RSGI/1wes TOPSAN]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wes OCA], [http://www.ebi.ac.uk/pdbsum/1wes PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wes RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/ING2_MOUSE ING2_MOUSE] Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).
-
 
+
== Evolutionary Conservation ==
-
'''Solution structure of PHD domain in inhibitor of growth family, member 1-like'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/1wes_consurf.spt"</scriptWhenChecked>
-
1WES is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WES OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wes ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: He F]]
-
[[Category: He, F.]]
+
[[Category: Inoue M]]
-
[[Category: Inoue, M.]]
+
[[Category: Kigawa T]]
-
[[Category: Kigawa, T.]]
+
[[Category: Muto Y]]
-
[[Category: Muto, Y.]]
+
[[Category: Shirouzu M]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Terada T]]
-
[[Category: Shirouzu, M.]]
+
[[Category: Yokoyama S]]
-
[[Category: Terada, T.]]
+
-
[[Category: Yokoyama, S.]]
+
-
[[Category: inhibitor of growth family]]
+
-
[[Category: nmr]]
+
-
[[Category: phd domain]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:35:13 2008''
+

Current revision

Solution structure of PHD domain in inhibitor of growth family, member 1-like

PDB ID 1wes

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wes"
Personal tools