Pleurotolysin
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load='' size='340' side='right' caption='Pleurotoxin A ( | + | <StructureSection load='' size='340' side='right' caption='Pleurotoxin A (blue and green) complex with pleurotoxin B (pink) (PDB code [[4v3a]])' scene='75/751804/Cv/1' pspeed='8'> |
== Function == | == Function == | ||
| - | '''Pleurotolysin''' (PTL) is a pore-forming cytolysin from ''Pleurotus ostreatus''. PTL is a two-component cytolysin composed of non-associated PTL A (17kDa) and PTL B (59kDa) which cooperatively cause leakage of potassium ions from human erythrocytes and swelling of the cells leading to colloid-osmotic hemolysis<ref>PMID:15084605</ref>. <scene name='75/751804/Cv/ | + | '''Pleurotolysin''' (PTL) is a pore-forming cytolysin from ''Pleurotus ostreatus''. PTL is a two-component cytolysin composed of non-associated '''PTL A''' (17kDa) and '''PTL B''' (59kDa) which cooperatively cause leakage of potassium ions from human erythrocytes and swelling of the cells leading to colloid-osmotic hemolysis<ref>PMID:15084605</ref>. <scene name='75/751804/Cv/4'>Pleurotoxin A complex with pleurotoxin B</scene> ([[4v3a]]). |
</StructureSection> | </StructureSection> | ||
| Line 25: | Line 25: | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D structures of pleurotolysin
Updated on 22-July-2024
References
- ↑ Tomita T, Noguchi K, Mimuro H, Ukaji F, Ito K, Sugawara-Tomita N, Hashimoto Y. Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex. J Biol Chem. 2004 Jun 25;279(26):26975-82. Epub 2004 Apr 14. PMID:15084605 doi:http://dx.doi.org/10.1074/jbc.M402676200
