5i6r

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==Crystal Structure of srGAP2 F-BARx WT Form-1==
==Crystal Structure of srGAP2 F-BARx WT Form-1==
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<StructureSection load='5i6r' size='340' side='right' caption='[[5i6r]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='5i6r' size='340' side='right'caption='[[5i6r]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i6r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I6R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I6R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6r OCA], [http://pdbe.org/5i6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i6r RCSB], [http://www.ebi.ac.uk/pdbsum/5i6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i6r ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i6r OCA], [https://pdbe.org/5i6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i6r RCSB], [https://www.ebi.ac.uk/pdbsum/5i6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i6r ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
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[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN]] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>
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[https://www.uniprot.org/uniprot/SRGP2_HUMAN SRGP2_HUMAN] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref> <ref>PMID:21148482</ref> <ref>PMID:22559944</ref>
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==See Also==
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*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Guez-Haddad, J]]
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[[Category: Homo sapiens]]
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[[Category: Isupov, M N]]
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[[Category: Large Structures]]
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[[Category: Opatowsky, Y]]
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[[Category: Guez-Haddad J]]
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[[Category: Sporny, M]]
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[[Category: Isupov MN]]
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[[Category: C280y]]
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[[Category: Opatowsky Y]]
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[[Category: Cakut]]
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[[Category: Sporny M]]
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[[Category: F-bar]]
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[[Category: Signaling protein]]
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[[Category: Srgap2]]
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Current revision

Crystal Structure of srGAP2 F-BARx WT Form-1

PDB ID 5i6r

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