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4zxf

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==Crystal Structure of a Soluble Variant of Monoglyceride Lipase from Saccharomyces Cerevisiae in Complex with a Substrate Analog==
==Crystal Structure of a Soluble Variant of Monoglyceride Lipase from Saccharomyces Cerevisiae in Complex with a Substrate Analog==
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<StructureSection load='4zxf' size='340' side='right' caption='[[4zxf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4zxf' size='340' side='right'caption='[[4zxf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zxf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZXF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zxf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZXF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4S7:1-{3-[(R)-HYDROXY(OCTADECYLOXY)PHOSPHORYL]PROPYL}TRIAZA-1,2-DIEN-2-IUM'>4S7</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zwn|4zwn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4S7:1-{3-[(R)-HYDROXY(OCTADECYLOXY)PHOSPHORYL]PROPYL}TRIAZA-1,2-DIEN-2-IUM'>4S7</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acylglycerol_lipase Acylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.23 3.1.1.23] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxf OCA], [https://pdbe.org/4zxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zxf RCSB], [https://www.ebi.ac.uk/pdbsum/4zxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxf OCA], [http://pdbe.org/4zxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zxf RCSB], [http://www.ebi.ac.uk/pdbsum/4zxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MGLL_YEAST MGLL_YEAST]] Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA).<ref>PMID:19529773</ref> <ref>PMID:20554061</ref>
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[https://www.uniprot.org/uniprot/MGLL_YEAST MGLL_YEAST] Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA).<ref>PMID:19529773</ref> <ref>PMID:20554061</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Lipase|Lipase]]
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*[[Lipase 3D Structures|Lipase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acylglycerol lipase]]
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[[Category: Large Structures]]
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[[Category: Aschauer, P]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Gruber, K]]
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[[Category: Aschauer P]]
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[[Category: Lichtenegger, J]]
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[[Category: Gruber K]]
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[[Category: Oberer, M]]
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[[Category: Lichtenegger J]]
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[[Category: Rengachari, S]]
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[[Category: Oberer M]]
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[[Category: Complex]]
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[[Category: Rengachari S]]
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[[Category: Hydrolase]]
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[[Category: Monoacylglycerol lipase]]
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[[Category: Monoglyceride lipase]]
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[[Category: Substrate analog]]
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Current revision

Crystal Structure of a Soluble Variant of Monoglyceride Lipase from Saccharomyces Cerevisiae in Complex with a Substrate Analog

PDB ID 4zxf

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