1wik

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[[Image:1wik.jpg|left|200px]]
 
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{{Structure
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==Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein==
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|PDB= 1wik |SIZE=350|CAPTION= <scene name='initialview01'>1wik</scene>
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<StructureSection load='1wik' size='340' side='right'caption='[[1wik]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1wik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WIK FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= RIKEN cDNA 2410003E11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wik OCA], [https://pdbe.org/1wik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wik RCSB], [https://www.ebi.ac.uk/pdbsum/1wik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wik ProSAT], [https://www.topsan.org/Proteins/RSGI/1wik TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wik OCA], [http://www.ebi.ac.uk/pdbsum/1wik PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wik RCSB]</span>
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[https://www.uniprot.org/uniprot/GLRX3_MOUSE GLRX3_MOUSE] Crucial regulator of cellular iron homeostasis and hemoglobin maturation (By similarity). Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. Has an essential function in embryogenesis.<ref>PMID:16809552</ref> <ref>PMID:18258855</ref> <ref>PMID:18929570</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wi/1wik_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1WIK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WIK OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wik ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Inoue M]]
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[[Category: Inoue, M.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Koshiba S]]
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[[Category: Koshiba, S.]]
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[[Category: Miyamoto K]]
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[[Category: Miyamoto, K.]]
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[[Category: Tomizawa T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: picot homology 2 domain]]
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[[Category: picot protein]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: thioredoxin like 2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:36:45 2008''
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Current revision

Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein

PDB ID 1wik

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