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5nuv

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==Structure of the WD40-domain of human ATG16L1==
==Structure of the WD40-domain of human ATG16L1==
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<StructureSection load='5nuv' size='340' side='right' caption='[[5nuv]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='5nuv' size='340' side='right'caption='[[5nuv]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nuv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NUV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nuv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NUV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nuv OCA], [http://pdbe.org/5nuv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nuv RCSB], [http://www.ebi.ac.uk/pdbsum/5nuv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nuv ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nuv OCA], [https://pdbe.org/5nuv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nuv RCSB], [https://www.ebi.ac.uk/pdbsum/5nuv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nuv ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/A16L1_HUMAN A16L1_HUMAN]] Crohn disease. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/A16L1_HUMAN A16L1_HUMAN] Crohn disease. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A16L1_HUMAN A16L1_HUMAN]] Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II.<ref>PMID:23376921</ref>
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[https://www.uniprot.org/uniprot/A16L1_HUMAN A16L1_HUMAN] Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II.<ref>PMID:23376921</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bajagic, M]]
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[[Category: Homo sapiens]]
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[[Category: Scrima, A]]
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[[Category: Large Structures]]
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[[Category: Atg16l1]]
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[[Category: Bajagic M]]
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[[Category: Protein binding]]
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[[Category: Scrima A]]
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[[Category: Seven-bladed beta-propeller]]
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[[Category: Wd40]]
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Current revision

Structure of the WD40-domain of human ATG16L1

PDB ID 5nuv

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