5x83

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==Structure of DCC FN456 domains==
==Structure of DCC FN456 domains==
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<StructureSection load='5x83' size='340' side='right' caption='[[5x83]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='5x83' size='340' side='right'caption='[[5x83]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X83 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5x83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X83 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [http://pdbe.org/5x83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [http://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.997&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x83 OCA], [https://pdbe.org/5x83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x83 RCSB], [https://www.ebi.ac.uk/pdbsum/5x83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x83 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
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[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[https://omim.org/entry/157600 157600]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
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[https://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref>
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==See Also==
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*[[Netrin receptor|Netrin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Finci, F I]]
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[[Category: Homo sapiens]]
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[[Category: Wang, J]]
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[[Category: Large Structures]]
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[[Category: Xiao, J]]
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[[Category: Finci FI]]
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[[Category: Axon guidance]]
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[[Category: Wang J]]
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[[Category: Dcc]]
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[[Category: Xiao J]]
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[[Category: Netrin-1]]
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[[Category: Signaling protein]]
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Current revision

Structure of DCC FN456 domains

PDB ID 5x83

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