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1e9d

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==Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP==
==Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP==
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<StructureSection load='1e9d' size='340' side='right' caption='[[1e9d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='1e9d' size='340' side='right'caption='[[1e9d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1e9d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E9D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1e9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2d|1e2d]], [[1e2e|1e2e]], [[1e2f|1e2f]], [[1e2g|1e2g]], [[1e2q|1e2q]], [[1e98|1e98]], [[1e99|1e99]], [[1e9a|1e9a]], [[1e9b|1e9b]], [[1e9c|1e9c]], [[1e9e|1e9e]], [[1e9f|1e9f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9d OCA], [https://pdbe.org/1e9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9d RCSB], [https://www.ebi.ac.uk/pdbsum/1e9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9d OCA], [http://pdbe.org/1e9d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e9d RCSB], [http://www.ebi.ac.uk/pdbsum/1e9d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9d ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_HUMAN KTHY_HUMAN] Catalyzes the conversion of dTMP to dTDP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/1e9d_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/1e9d_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Thymidylate kinase|Thymidylate kinase]]
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DTMP kinase]]
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[[Category: Homo sapiens]]
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[[Category: Brundiers, R]]
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[[Category: Large Structures]]
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[[Category: Goody, R S]]
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[[Category: Brundiers R]]
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[[Category: Konrad, M]]
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[[Category: Goody RS]]
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[[Category: Lavie, A]]
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[[Category: Konrad M]]
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[[Category: Ostermann, N]]
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[[Category: Lavie A]]
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[[Category: Padiyar, S]]
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[[Category: Ostermann N]]
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[[Category: Reintein, J]]
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[[Category: Padiyar S]]
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[[Category: Schlichting, I]]
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[[Category: Reintein J]]
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[[Category: Veit, T]]
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[[Category: Schlichting I]]
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[[Category: P-loop]]
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[[Category: Veit T]]
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[[Category: Phosphotransferase]]
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[[Category: Thymidylate kinase]]
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[[Category: Transferase]]
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Current revision

Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP

PDB ID 1e9d

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